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首页> 外文期刊>The Canadian journal of clinical pharmacology =: Journal canadien de pharmacologie clinique >An amantadine hydrochloride dosing program adjusted for renal function during an influenza outbreak in elderly institutionalized patients.
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An amantadine hydrochloride dosing program adjusted for renal function during an influenza outbreak in elderly institutionalized patients.

机译：盐酸金刚烷胺给药方案针对老年住院患者的流感暴发期间的肾功能进行了调整。

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OBJECTIVE: We tested the hypothesis that individualized dosing of amantadine hydrochloride, based upon a patient's creatinine clearance, would maintain efficacy against influenza A infection while reducing adverse reactions to the drug. DESIGN: A prospective cohort study PARTICIPANTS: Residents of two nursing homes with a total population of 301 individuals INTERVENTION: Amantadine hydrochloride was administered prophylactically subsequent to a confirmed influenza A outbreak. The dose was individualized based upon the resident's calculated creatinine clearance. RESULTS: The concentration of amantadine hydrochloride in the circulation at steady-state in patients who had doses adjusted for their estimated creatinine clearance was not different by nursing home or by sex of the resident. The mean concentration was within the 95% CI for the target concentration of 1.6 micromol/L. Side effects were modest and did not require discontinuation of amantadine hydrochloride therapy. Only the presence of concurrentinfluenza-like illness was significantly associated with adverse events during amantadine hydrochloride therapy. CONCLUSIONS: Adjustment of doses for estimated creatinine clearance is feasible in a long term care facility when amantadine hydrochloride is indicated for influenza A prophylaxis. These data form the basis for a definitive study of amantadine hydrochloride efficacy in patients with reduced renal function. Concurrent influenza-like illness is likely to confound attempts to associate adverse reactions to the administration of amantadine hydrochloride therapy.
机译：目的：我们检验了以下假设：根据患者的肌酐清除率，单独使用盐酸金刚烷胺盐酸盐可维持抗甲型流感的功效，同时减少对该药物的不良反应。设计：一项前瞻性队列研究参与者：两个疗养院的居民，总人口301人干预：在确诊的甲型流感爆发后，预防性给予盐酸金刚烷胺。根据患者的肌酐清除率对剂量进行个体化。结果：调整了估计的肌酐清除率的患者在稳态血液循环中盐酸金刚烷胺的浓度随疗养院或住院医生的性别而变化。平均浓度在目标浓度1.6 micromol / L的95％CI之内。副作用适中，不需要停用盐酸金刚烷胺治疗。在盐酸金刚烷胺治疗期间，只有并发流感样疾病的存在与不良事件显着相关。结论：当指示盐酸金刚烷胺可预防甲型流感时，在长期护理机构中调整估计肌酐清除率的剂量是可行的。这些数据构成了最终研究盐酸金刚烷胺对肾功能降低的患者疗效的基础。并发流感样疾病可能会使尝试将不良反应与盐酸金刚烷胺治疗相关联的尝试混淆。

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