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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Are Tight Glycemic Targets Achieved Through Intensive Insulin Infusion Still Applicable in the Intensive Care Unit?
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Are Tight Glycemic Targets Achieved Through Intensive Insulin Infusion Still Applicable in the Intensive Care Unit?

机译：重症监护病房是否仍然可以通过密集的胰岛素输注达到严格的血糖目标？

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摘要

Clinical trials have shown that over 98% of patients in the intensive care unit (ICU) require insulin therapy to maintain normoglycemia.Hyperglycemia is associated with higher morbidity and mortality for patients with traumatic brain injuries," sepsis, hematologic malignancy,and nondiabetic stroke. Among those who have had myocardial infarction, hypoglycemia is associated with an increased risk of congestive heart failure and cardiogenic shock. However, the use of intensive insulin therapy (IIT) to manage hyperglycemia in the ICU is a controversial topic. Although some studies have shown that IIT improves outcomes, recent trials have questioned the benefit of IIT in light of the potential for increased frequency of hypoglycemia. The question to be addressed here is: Does implementing IIT for all ICU patients improve outcomes? Various trials will be discussed to illustrate that treatment of hyperglycemia with IIT does improve outcomes.
机译：临床试验表明，重症监护病房（ICU）中超过98％的患者需要胰岛素治疗以维持血糖正常。高血糖与颅脑外伤，败血症，血液系统恶性肿瘤和非糖尿病性卒中患者的发病率和死亡率较高相关。在患有心肌梗塞的患者中，低血糖与充血性心力衰竭和心源性休克的风险增加相关，但是，在ICU中使用强化胰岛素治疗（IIT）来控制高血糖是一个有争议的话题，尽管一些研究表明IIT可以改善预后，鉴于低血糖频率增加的可能性，最近的试验对IIT的益处提出了质疑，这里要解决的问题是：是否对所有ICU患者实施IIT都能改善预后？ IIT治疗高血糖确实可以改善预后。

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