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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Target symptoms and outcome measures: cognition.
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Target symptoms and outcome measures: cognition.

机译：目标症状和结果指标：认知。

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The Cognitive section of the Alzheimer's Disease Assessment Scale (ADAS-Cog) remains the most widely used cognitive measure in dementia trials although it does not assess attention, executive function, or agnosia. Designed for use in Alzheimer's disease (AD), it may not be ideal in assessing patients with other diagnoses. The ADAS-Cog differentiates between AD patients, patients with Mild Cognitive Impairment, and normal controls. It has been used in trials of drugs for vascular and mixed dementia and dementia with Lewy bodies. It is not clear that the ADAS-Cog is adequate for assessing cognition in frontotemporal dementia. Well-validated aphasia batteries, such as the Western Aphasia Battery, can be used to assess language. Brief tests of frontal function such as the Frontal Assessment Battery or the Executive Interview might be useful additions in frontotemporal dementia trials. The most widely used assessment tool for patients with advanced dementia is the Severe Impairment Battery. The domains tested are analogous to those assessed by the ADAS-Cog. The Mini-Mental State Exam and the Modified Mini-Mental State Examination are useful in stratifying patients for trial entry. Cognitive measures better tailored to the diseases in question are needed for non-Alzheimer dementias.
机译：阿尔茨海默氏病疾病评估量表（ADAS-Cog）的“认知”部分仍然是痴呆症试验中使用最广泛的认知方法，尽管它没有评估注意力，执行功能或不可知性。设计用于阿尔茨海默氏病（AD），在评估具有其他诊断的患者时可能不是理想的选择。 ADAS-Cog可以区分AD患者，轻度认知障碍患者和正常对照。它已用于血管性和混合性痴呆以及路易小体痴呆的药物试验中。尚不清楚ADAS-Cog是否足以评估额颞痴呆的认知度。经过验证的失语症电池（例如西方失语症电池）可用于评估语言。在额颞痴呆试验中，对额叶功能进行简短测试（例如额叶评估电池组或执行面试）可能是有用的补充。晚期痴呆患者使用最广泛的评估工具是严重受损电池。测试的域类似于ADAS-Cog评估的域。迷你精神状态考试和经修改的迷你精神状态考试可用于对患者进行分层试验。非阿尔茨海默氏痴呆症需要更好地针对所关注疾病的认知措施。

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