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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Metastatic melanoma to the pituitary gland.
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Metastatic melanoma to the pituitary gland.

机译：垂体转移性黑色素瘤。

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摘要

BACKGROUND: Metastasis to the pituitary gland is unusual, and occurs most often in patients with carcinomas of the breast or lung. Despite its propensity for spread to the brain, metastatic melanoma has rarely been described within the sella. METHODS: We report two cases of malignant melanoma pathologically confirmed within the pituitary, both metastatic from a primary site on the chest wall. In each patient, transsphenoidal resection of the tumor was incomplete and each received local radiotherapy after surgery. RESULTS: One patient recurred quickly and developed brain metastasis as well. He died four months after resection of the pituitary metastasis, but the second patient survived six months without recurrence. As intrasellar metastasis portends widespread systemic disease and may be synchronous with parenchymal brain metastasis, survival in such patients is limited regardless of adjunctive therapy. CONCLUSIONS: Such cases are likely to arise more commonly in future due to the increasing incidence of melanoma. Identifying them by imaging alone is difficult due to inconsistent signal characteristics on MRI (as shown by these cases) and the confusion introduced by any associated intratumoral hemorrhage.
机译：背景：垂体转移是不常见的，且最常见于患有乳腺癌或肺癌的患者。尽管转移性黑色素瘤易于扩散到大脑，但在蝶鞍中很少有人描述过转移性黑色素瘤。方法：我们报告了两例垂体内经病理证实的恶性黑色素瘤病例，均从胸壁原发部位转移。在每例患者中，肿瘤经蝶窦切除术均不完全，并且均在手术后接受了局部放疗。结果：1例患者复发快，并发生脑转移。他在垂体转移瘤切除后四个月死亡，但第二例患者存活了六个月而未复发。由于肌内转移预示着广泛的全身性疾病，并且可能与实质性脑转移同步发生，因此无论辅助治疗如何，此类患者的生存都受到限制。结论：由于黑色素瘤的发病率增加，这种情况将来可能会更加普遍。由于MRI上的信号特征不一致（如这些情况所示）以及任何相关的肿瘤内出血引起的混淆，仅凭成像很难识别它们。

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