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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Axial signs and magnetic resonance imaging correlates in Parkinson's disease.
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Axial signs and magnetic resonance imaging correlates in Parkinson's disease.

机译：帕金森氏病与轴征和磁共振成像有关。

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BACKGROUND: Age-related brain changes may contribute to axial features in Parkinson's disease (PD). OBJECTIVES: To determine if ventricular volume and white matter high signal changes (WMC) are related to motor signs in PD and controls independent of age. METHODS: Patients were rated with the Unified Parkinson's Disease Rating Scale (subscore A: tremor, rigidity, bradykinesia, and facial expression; subscore B: speech and axial impairment). Steps and time taken to walk 9.144 meters were measured. Total ventricular volume (TVV) and intracranial volume (ICV) were measured on T1-weighted MRI using manual tracing software. WMC were rated on axial T2-weighted, dual-echo or FLAIR MR images using a visual scale. RESULTS: TVV (cm3) (PD: 36.48 +/- 15.93; controls: 32.16 +/- 14.20, p = 0.21) and WMC did not differ between groups (PD: 3.7 +/- 4.2; controls: 3.2 +/- 3.1, p = 0.55). Age correlated positively with ICV-corrected TVV and WMC in PD (cTVV: r = 0.48, p = 0.003; WMC: r = 0.42, p = 0.01) and controls (cTVV: r 0.31, p 0.01) but not subscore A (r = 0.25, p = 0.14) correlated with cTVV in PD. Steps and walking time correlated with cTVV and WMC in PD; cadence correlated with cTVV and steps with WMC in controls. Age-adjustment eliminated correlations. CONCLUSION: Subscore B, but not subscore A correlated positively with ventricular volume in PD, though this association was accounted for by age. Age-related brain change super-imposed on PD may contribute to axial features.
机译：背景：与年龄相关的大脑变化可能有助于帕金森氏病（PD）的轴向特征。目的：确定心室容积和白质高信号变化（WMC）是否与PD中的运动征象有关，并且与年龄无关。方法：用帕金森病综合评分量表对患者进行评分（评分A：震颤，僵硬，运动迟缓和面部表情;评分B：言语和轴向障碍）。测量了行走9.144米所需的步骤和时间。使用手动跟踪软件在T1加权MRI上测量总心室体积（TVV）和颅内体积（ICV）。使用可视标尺在轴向T2加权，双回波或FLAIR MR图像上对WMC进行评级。结果：TVV（cm3）（PD：36.48 +/- 15.93;对照：32.16 +/- 14.20，p = 0.21），WMC在两组之间没有差异（PD：3.7 +/- 4.2;对照：3.2 +/- 3.1 ，p ＝ 0.55）。年龄与PD中经ICV校正的TVV和WMC正相关（cTVV：r = 0.48，p = 0.003; WMC：r = 0.42，p = 0.01）和对照（cTVV：r 0.31，p 0.01），但与A分无关（r = 0.25，p = 0.14）与PD中的cTVV相关。 PD中的步伐和步行时间与cTVV和WMC相关;节奏与cTVV相关，而步阶与WMC相关。年龄调整消除了相关性。结论：尽管B分值与年龄相关，但B分值与PD的心室容积呈正相关。叠加在PD上的与年龄有关的脑部变化可能有助于轴突特征。

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