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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Tumor effects on cerebral white matter as characterized by diffusion tensor tractography.
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Tumor effects on cerebral white matter as characterized by diffusion tensor tractography.

机译：肿瘤对脑白质的影响以弥散张量张量成像为特征。

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摘要

BACKGROUND: Diffusion tensor MRI fiber tractography (DTT) is the first non-invasive in vivo technique for delineating specific white matter (WM) tracts. In cerebral neoplasm, DTT can be used to illustrate the relationship of the tumor with respect to adjacent WM trajectories. METHODS: Fiber tractography was used in this study to assess tumor-induced changes in WM trajectories in three cases of cerebral neoplasm: glioblastoma multiforme, meningioma, and anaplastic astrocytoma. RESULTS: Three patterns of WM alteration were identified: 1) disruption, 2) displacement, and 3) infiltration. Tumor disruption of WM tracts was observed in glioblastoma multiforme, which terminated fibers crossing the corpus callosum. In meningioma, DTT illustrated bulk displacement of the corticospinal tract in the affected hemisphere as well as preservation of the deviated axons. In anaplastic astrocytoma, fiber tracking demonstrated disruption of WM tracts at the tumor origin as well as intact axons through areas of tumor infiltration. CONCLUSIONS: Fiber tracking results correlated with the clinical and histopathological features of the tumor. Larger case series will be required to determine if fiber tracking can add accuracy to existing imaging methods for grading tumors.
机译：背景技术：扩散张量MRI纤维束成像（DTT）是第一种用于描绘特定白质（WM）束的非侵入性体内技术。在脑肿瘤中，DTT可用于说明肿瘤与相邻WM轨迹的关系。方法：纤维束摄影术被用于评估三例多发性胶质母细胞瘤，脑膜瘤和间变性星形胶质细胞瘤的肿瘤在WM轨迹中肿瘤诱导的变化。结果：确定了WM改变的三种模式：1）破裂，2）移位和3）浸润。在多形性胶质母细胞瘤中观察到WM道的肿瘤破坏，这终止了穿过crossing体的纤维。在脑膜瘤中，DTT显示了受影响的半球中皮质脊髓束的大量移位以及轴突的保留。在间变性星形细胞瘤中，纤维追踪显示了在肿瘤起源处的WM束的破坏以及通过肿瘤浸润区域的完整轴突的破坏。结论：纤维追踪结果与肿瘤的临床和组织病理学特征相关。将需要更大的病例系列来确定纤维追踪是否可以为现有的肿瘤分级成像方法增加准确性。

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