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首页> 外文期刊>The Canadian journal of clinical pharmacology =: Journal canadien de pharmacologie clinique >Longitudinal outcomes of gastrointestinal symptoms in canada (LOGIC): KEY factors for an effective patient retention in observational studies
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Longitudinal outcomes of gastrointestinal symptoms in canada (LOGIC): KEY factors for an effective patient retention in observational studies

机译：加拿大胃肠道症状的纵向结果（LOGIC）：观察研究中有效保留患者的关键因素

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Background Longitudinal Outcomes of Gastrointestinal symptoms in Canada (LOGIC) is an ongoing study on irritable bowel syndrome (IBS) treatment patterns and health outcomes in routine Canadian clinical practice. Advancements in understanding IBS, a chronic multifaceted GI disorder, may be possible through methodical observational studies. The objective of this paper is to describe site recruitment techniques and extensive subject follow-up methodology used to facilitate a high return rate of questionnaires from this population-based study of subjects with IBS. Methods Invitation letters along with protocol synopses and preliminary site assessment questionnaires were faxed to potential sites across Canada. There were 1,556 subjects enrolled in this study from general practitioner sites (GP) and specialist sites (SP) in Canada. Subjects were compensated for the return of questionnaires reporting symptoms, quality of life, productivity, healthcare and resource utilization at baseline, Month 1, 3, 6, 9, and 12. Upon the return of questionnaires, subjects received thank you cards which included a reminder of the next questionnaire's due date. If subject questionnaires were not received within 2 weeks after the due date, the subjects received a reminder letter in the mail. Results The methodology in the LOGIC study allowed for a high patient questionnaire return rate (89%) through extensive subject reminders and follow-up. Subject participation throughout the study was not found to be linked to study site size or type (GP or SP). Conclusion Questionnaire based observational studies may benefit from focusing resources on increasing questionnaire return rates to effectively maintain data reliability and also reduce non-response bias.
机译：背景技术加拿大胃肠道症状的纵向结果（LOGIC）是加拿大常规临床实践中有关肠易激综合征（IBS）治疗模式和健康结果的一项持续研究。通过系统的观察性研究，可能会促进对IBS（一种慢性多面GI障碍）的理解。本文的目的是描述现场招募技术和广泛的受试者随访方法，以促进这项基于人群的IBS受试者研究问卷的高回报率。方法将邀请函以及协议大纲和初步现场评估调查表传真至加拿大各地的潜在站点。有1,556名受试者从加拿大的全科医生（GP）和专家（SP）入选本研究。受试者在基线，第1、3、6、9和12月基线时症状，生活质量，生产率，医疗保健和资源利用情况的调查问卷的返还获得了补偿，在返还问卷调查后，受试者会收到感谢卡，其中包括提醒下一个问卷的到期日。如果在截止日期后的两周内未收到主题调查表，则主题会在邮件中收到提醒函。结果LOGIC研究中的方法通过广泛的主题提醒和随访，使患者问卷调查表的返回率很高（89％）。未发现整个研究过程中的受试者参与与研究部位的大小或类型（GP或SP）有关。结论基于问卷调查的观察性研究可能会受益于将资源集中用于提高问卷的返回率，从而有效地保持数据的可靠性并减少无答复的偏见。

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