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首页> 外文期刊>The Canadian journal of clinical pharmacology =: Journal canadien de pharmacologie clinique >Normal distribution of palpebral fissure lengths in Canadian school age children
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Normal distribution of palpebral fissure lengths in Canadian school age children

机译：加拿大学龄儿童的睑裂长度正态分布

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Background: Fetal alcohol syndrome (FAS) includes the facial dysmorphic feature of short palpebral fissures (PFs) and short PFs are a key physical marker for identifying children with FAS and some other rarer conditions. There is concern that normative data on PFs now available may not reflect all racial/ethnic groups and might be inaccurate in general. Objectives: To accomplish a large population based study that would accurately determine normative PF values across the full diversity of the Canadian school age population. Methods: A normative sample of school age children was identified in Vancouver, British Columbia and Winnipeg, Manitoba to reflect the diversity of racial and national groups in Canada. The sample included students in grades 2, 4, 6, 8, and 10 from 17 schools in Vancouver and 31 schools in Winnipeg. Schools were selected based on racial diversity obtained from data from the 2001 Statistics Canada census. 1064 students in Vancouver and 1033 students in Winnipeg were photographed in a standardized way. Photographs were analyzed using a computerized method. Results: Analysis demonstrated that PFs do grow with age and there is a slight but meaningful difference between boys and girls in each age group. It is possible to define Canadian standards without reference to racial or ethnic origin. Conclusion: Mean results with norms and standard deviations are presented in figures for clinical use and are clinically smaller than those found in the most commonly used reference book.
机译：背景：胎儿酒精综合症（FAS）包括短睑裂（PFs）的面部畸形特征，而短PFs是识别患有FAS和其他罕见疾病的儿童的重要物理标志。令人担忧的是，目前可获得的关于PF的规范性数据可能无法反映所有种族/族裔群体，并且总体上可能不准确。目标：完成一项基于人口的大型研究，该研究将准确确定加拿大学龄人口全部多样性中的规范PF值。方法：在不列颠哥伦比亚省的温哥华市和曼尼托巴省的温尼伯市确定了一个学龄儿童的标准样本，以反映加拿大种族和民族的多样性。样本包括来自温哥华的17所学校和温尼伯的31所学校的2、4、6、8和10年级的学生。根据2001年加拿大统计局人口普查数据获得的种族多样性选择学校。以标准化的方式拍摄了温哥华的1064名学生和温尼伯的1033名学生。使用计算机化方法分析照片。结果：分析表明，PFs确实随年龄增长，并且每个年龄段的男孩和女孩之间都有细微但有意义的差异。可以在不参考种族或民族血统的情况下定义加拿大标准。结论：具有标准和标准偏差的平均结果显示在临床使用的数字中，并且在临床上比在最常用的参考书中发现的要小。

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