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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Stabilite et compatibility de I'association ondansetron-methylprednisolone en solution
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Stabilite et compatibility de I'association ondansetron-methylprednisolone en solution

机译：stab i李特ET compatibility dei association on但set Ron-methyl pre D你solo呢en solution

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摘要

Objective: To evaluate the compatibility and stability of ondansetron and methylprednisolone when prepared in combination in the same infusion bag, with a view to preparing large quantities of this drug combination in advance and storing it until needed for patient administration.Methods; Combined solutions were prepared with concentrations of 0.16 mg/mL ondansetron and 2.4 mg/mL of methylprednisolone in 2 different solutions: 5 % glucose and 0.9% sodium chloride. Two types of bags (MacoPharma polyolefins and Fresenius Freeflex polypropylene) were used to determine the impact of bag material on the stability and compatibility of the mixture. The bags were stored at room temperature (22degC + 3degC, with or without protection from light) or at 4degC +- 2degC. The concentration of each active ingredient was evaluated with a high-performance liquid chromatography method, and physical compatibility was assessed by visual inspection of the bags.Results: The combination of ondansetron and methylprednisolone prepared in the same infusion bag at the concentrations tested in this study could be stored for 2 days at room temperature or 4 days at 4degC when prepared in 5% glucose and for 3 days at room temperature or 4 days at 4degC when prepared in 0.9% sodium chloride. The nature of the bag material (polypropylene or polyolefins) and exposure to light did not affect stability.Conclusions: The results of this study indicate that the bags containing a mixture of ondansetron and methylprednisolone can be stored for a maximum of 4 days at 4degC (refrigerated) and a maximum of 2 days at room temperature. These data confirm that it is possible to prepare bags in advance and to keep them ready for use upon prescribing by the medical team, without the delay imposed by preparation.
机译：目的：评价恩丹西酮和甲基强的松龙在同一输液袋中联合使用时的相容性和稳定性，以期提前制备大量这种药物组合并保存直至患者使用。混合溶液的浓度为0.16 mg / mL恩丹西酮和2.4 mg / mL甲基泼尼松龙在2种不同溶液中制备：5％葡萄糖和0.9％氯化钠。两种类型的袋子（MacoPharma聚烯烃和Fresenius Freeflex聚丙烯）用于确定袋子材料对混合物的稳定性和相容性的影响。这些袋在室温（22℃+ 3℃，有或没有避光保护）或4℃±2℃下保存。采用高效液相色谱法评估每种活性成分的浓度，并通过目视检查包装袋评估其物理相容性。结果：在同一输液袋中以本研究中测试的浓度制备的恩丹西酮和甲基泼尼松龙的组合当在5％葡萄糖中制备时，可在室温下保存2天或在4℃下保存4天;在0.9％氯化钠中制备时，可在室温下保存3天或在4℃下保存4天。袋子材料（聚丙烯或聚烯烃）的性质和暴露于光线不会影响稳定性。结论：本研究结果表明，含有恩丹西酮和甲基泼尼松龙混合物的袋子在4°C下最多可保存4天（冷藏），最多在室温下放置2天。这些数据证实，可以事先准备好袋子，并在医疗队开处方后随时准备使用，而不会因准备工作而造成延误。

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