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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Use of Parenteral Fish Oil to Reverse Cholestasis Induced by Parenteral Nutrition in Infants with Intestinal Failure: Single-Centre Case Series
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Use of Parenteral Fish Oil to Reverse Cholestasis Induced by Parenteral Nutrition in Infants with Intestinal Failure: Single-Centre Case Series

机译：使用肠胃外鱼油逆转肠外营养导致肠衰竭婴儿的胆汁淤积：单中心病例系列

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摘要

Published data assessing the efficacy and toxicity of omega-3 fatty acid emulsion in children are limited.1'3 Until recently, children requiring long-term parenteral nutrition who experienced parenteral nutrition-associated liver disease (PNALD) were likely to die from infection or liver disease before receiving a small bowel and/or liver transplant.4 With the introduction of parenteral fish oil (10% long-chain omega-3 fatty acid emulsion; Omegaven, Fresenius Kabi, Bad Homburg, Germany), originally indicated for use in combination with a soybean oil-based lipid emulsion (Intralipid), we have been able to reverse this life-threatening condition in several infants without the need for transplantation. We present our experience with parenteral administration of fish oil in 8 infants with PNALD. Verbal informed consent for publication was obtained from the patients' guardians. No ethics approval was required by our institution.
机译：评估omega-3脂肪酸乳剂对儿童的功效和毒性的公开数据有限。1'3直到最近，需要长期胃肠外营养且经历了胃肠外营养相关性肝病（PNALD）的儿童很可能死于感染或死亡。接受小肠和/或肝移植之前的肝病。4引入肠胃外鱼油（10％长链omega-3脂肪酸乳液; Omegaven，费森尤斯·卡比，德国巴特洪堡，德国）最初用于与基于大豆油的脂质乳液（Intralipid）配合使用，我们已经能够逆转几名婴儿的这种危及生命的状况，而无需进行移植。我们介绍了对8例PNALD婴儿进行鱼油肠胃外给药的经验。从患者监护人处获得口头知情同意发表。我们的机构不需要道德批准。

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