• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Management of antiepileptic drugs following epilepsy surgery: a review.
【24h】

Management of antiepileptic drugs following epilepsy surgery: a review.

机译：癫痫手术后抗癫痫药物的管理：综述。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The favourable impact of surgery for intractable epilepsy on seizures is well documented. However, few studies have determined what changes in antiepileptic drug (AED) therapy occur following surgery. Alterations in AED blood levels in the immediate postoperative period can result in breakthrough seizures. In long term follow-up, one-third to one-half of seizure-free patients after temporal lobectomy, the most common type of epilepsy surgery, still require AED treatment which usually has been reduced from polytherapy to monotherapy. In our study of 93 patients followed two years after temporal lobectomy, polytherapy decreased from 78% before surgery to 14% postoperatively, while medication was discontinued in 44%. Early reduction from polytherapy to monotherapy can often be carried out in the immediate postoperative period but the most appropriate timing of cessation of AED treatment has yet to be determined. Patients undergoing extratemporal resections and other forms of epilepsy surgery associated with less favourable postoperative seizure control may achieve comparatively less reduction in antiepileptic medication. We generally do not recommend stopping AEDs prior to one year after surgery.
机译：手术治疗顽固性癫痫对癫痫发作的有利影响已得到充分证明。但是，很少有研究确定手术后抗癫痫药物（AED）疗法会发生什么变化。术后即刻AED血液水平的改变可导致癫痫发作。在长期随访中，颞叶切除术（最常见的癫痫手术类型）后无癫痫发作患者的三分之一至一半仍需要AED治疗，通常已从多药治疗改为单药治疗。在我们对93例患者进行颞叶切除术后的研究中，多药疗法从手术前的78％降至术后的14％，而停药的比例为44％。通常可以在术后即刻从早期将多药疗法减为单药疗法，但尚未确定停止AED治疗的最合适时机。接受颞下切除术和其他形式的癫痫手术而术后癫痫发作控制较差的患者，抗癫痫药物的减少相对较少。我们通常不建议在手术后一年之前停止AED。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号