Disease staging and milestones.

Rabheru K

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Disease staging and milestones.

机译：疾病分期和里程碑。

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This new section to the guidelines was added due to the recognition that clinical milestones are useful indices of the progression of dementia in patients with Alzheimer's disease and could help in the development of stage-specific targeted therapy. This review specifically looks at clinical milestones that could be used in clinical trials, such as global function, function, behaviour, caregiver burden, and quality of life milestones. It also addresses the possible use of biological and surrogate markers for use as milestones--which may eventually replace clinical milestones. It concludes that current definitions of dementia must be broadened beyond cognition alone to include some of the domains listed.

机译：由于认识到临床里程碑是阿尔茨海默氏病患者痴呆症发展的有用指标，并且可能有助于开发阶段特异性靶向治疗，因此增加了该指南的新部分。这篇综述专门研究了可用于临床试验的临床里程碑，例如整体功能，功能，行为，护理人员负担和生活质量里程碑。它还解决了可能使用生物标志物和替代标志物作为里程碑的问题-最终可能会取代临床里程碑。结论是，目前对痴呆症的定义必须扩大到仅认知以外的领域，以包括所列的某些领域。

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《The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques》 |2007年第1期|共5页
作者
Rabheru K;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Clinical; Dementia; With staging; physiological aspects; Disease; 痴呆; 疾病;

机译：Clinical;Dementia;With staging;physiological aspects;Disease;痴呆;疾病;

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Disease staging and milestones.

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