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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Memory performance in HIV/AIDS--a prospective case control study.
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Memory performance in HIV/AIDS--a prospective case control study.

机译：HIV / AIDS中的记忆表现-前瞻性病例对照研究。

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BACKGROUND: Memory impairment, usually impaired retrieval of information, has been described in HIV/AIDS, especially among those with severe illness. Neuro-cognitive disturbances in HIV/AIDS have been linked to poor quality of life and medication adherence. This prospective, case-control study was designed to assess the verbal and non-verbal memory as well as the attention abilities of Nigerian Africans with HIV/AIDS and correlate their performances with their CD4+ T lymphocytes (CD4+) counts. METHODS: A total of 288 randomly selected subjects, comprising 96 HIV-positive symptomatic patients, 96 HIV-positive asymptomatic patients and 96 HIV-negative controls, participated in the study. The subjects were age-, sex-, and level of education matched. The Recognition Memory Test and Choice Reaction Time tasks, components of the computer-assisted neuropsychological tests battery- the Iron Psychology 'FePsy' were used for cognitive assessments. RESULTS: The mean memory scores of the HIV-positive asymptomatic subjects did not differ significantly from the controls (p > 0.05) but the HIV-positive symptomatic subjects' scores were significantly lower than the controls (p < 0.05). Both HIV-positive groups had psychomotor slowing and impaired attention (p < 0.05). The HIV-positive subjects with CD4+ counts < 200/microl and between 200 and 499/microl had significant memory impairment (p < 0.001 and p < 0.001 respectively) but there was no significant impairment among those with count > or = 500/microl. Impaired ability for sustained attention was however present irrespective of the CD4+ level relative to controls (p < 0.001). CONCLUSIONS: We concluded that there was no significant memory disturbance among HIV-positive asymptomatic subjects despite the presence of impaired attention and psychomotor slowing, and that the severity of immune suppression (as indicated by the CD4+ T lymphocytes count) is a strong determinant of cognitive decline in HIV/AIDS.
机译：背景：在艾滋病毒/艾滋病中，尤其是在那些患有严重疾病的人中，已经描述了记忆障碍，通常是信息的获取障碍。艾滋病毒/艾滋病的神经认知障碍与生活质量低下和药物依从性有关。这项前瞻性，病例对照研究旨在评估尼日利亚非洲人感染艾滋病毒/艾滋病后的言语和非言语记忆以及注意能力，并将其表现与其CD4 + T淋巴细胞（CD4 +）计数相关联。方法：总共288名随机选择的受试者参加了研究，其中包括96例HIV阳性症状患者，96例HIV阳性无症状患者和96例HIV阴性对照。受试者的年龄，性别和受教育程度均相匹配。认知记忆测试和选择反应时间任务是计算机辅助神经心理学测试电池的组成部分-铁心理学“ FePsy”用于认知评估。结果：HIV阳性无症状受试者的平均记忆得分与对照组无显着差异（p> 0.05），但HIV阳性有症状受试者的得分显着低于对照组（p <0.05）。两个HIV阳性组都有精神运动减慢和注意力受损（p <0.05）。 CD4 +计数<200 /微升且200-499 /微升之间的HIV阳性受试者有明显的记忆障碍（分别为p <0.001和p <0.001），但计数>或= 500 /μl的受试者中无显着损伤。但是，相对于对照组，无论CD4 +水平如何，持续注意力的能力均受损（p <0.001）。结论：我们的结论是，尽管存在注意力障碍和精神运动减慢，但在HIV阳性无症状受试者中并没有明显的记忆障碍，而且免疫抑制的严重程度（如CD4 + T淋巴细胞计数所示）是认知能力的重要决定因素艾滋病毒/艾滋病的下降。

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