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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Multiple sclerosis: change in health-related quality of life over two years.
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Multiple sclerosis: change in health-related quality of life over two years.

机译：多发性硬化症：两年内与健康相关的生活质量发生变化。

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BACKGROUND: Cross-sectional research has demonstrated poorer function and health-related quality of life (HRQOL) in those with multiple sclerosis (MS) but less is known about change over time. The goals of this study were to measure change in HRQOL and identify factors associated with change. METHODS: HRQOL was assessed at baseline and annually over two subsequent years using the Multiple Sclerosis Quality of Life Inventory. Function was assessed using the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite. Annualized rate of change was calculated for all twenty outcomes. Mixed effects modeling (univariate followed by multivariate) was used to examine the associations among patient characteristics and the age- and sex-adjusted Physical Component Summary (PCS) and Mental Component Summary (MCS) at study initiation and over the two years of follow-up. RESULTS: Of 300 participants, 288 (96%) provided at least one assessment and are included in this analysis. Although 14 of the 20 outcomes showed a mean decline, only two (SF-36 physical function, p=0.018 and the EDSS, p<0.001) were statistically significant. The SF-36 social function showed a significant improvement (p=0.031). Only two variables were significantly associated with a decreased rate of decline or improvement over two years, including being female (PCS, p=0.001) and use of visiting nurse services (MCS, p<0.001). CONCLUSIONS: HRQOL is relatively stable over two years of follow-up, particularly for mentally-oriented outcomes. Further research with a longer period of follow-up is needed to provide additional insight into factors associated with change in HRQOL in patients with MS.
机译：背景：横断面研究表明，多发性硬化症（MS）患者的功能和与健康相关的生活质量（HRQOL）较差，但随着时间的推移，人们对其知之甚少。这项研究的目的是测量HRQOL的变化并确定与变化相关的因素。方法：使用多发性硬化症生活质量量表对HRQOL进行基线评估，并在随后的两年中每年进行评估。使用扩展的残疾状态量表（EDSS）和多发性硬化症功能复合材料评估功能。计算所有二十个结果的年变化率。在研究开始时和随后的两年中，使用混合效应模型（单变量，然后是多元变量）来检查患者特征与年龄和性别调整后的身体成分摘要（PCS）和心理成分摘要（MCS）之间的关联。向上。结果：在300名参与者中，有288名（96％）提供了至少一项评估，并包括在该分析中。尽管20项结果中有14项显示平均下降，但只有两项（SF-36身体机能，p = 0.018和EDSS，p <0.001）在统计学上显着。 SF-36社交功能显示出显着改善（p = 0.031）。只有两个变量与两年内下降或改善率的下降显着相关，包括女性（PCS，p = 0.001）和就诊护士服务的使用（MCS，p <0.001）。结论：HRQOL在两年的随访中相对稳定，尤其是对于以心理为导向的结果。需要进行更长时间的随访研究，以进一步了解与MS患者HRQOL变化相关的因素。

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