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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Statins may increase intracerebral hemorrhage volume.
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Statins may increase intracerebral hemorrhage volume.

机译：他汀类药物可能会增加脑出血量。

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BACKGROUND: Some studies have suggested an association between hypocholesterolemia and intracerebral hemorrhage (ICH). In the SPARCL trial, statin use increased ICH risk. We tested the hypothesis that use of statins affects the volume of spontaneous ICH and contributes to the progression of ICH volume between baseline and follow-up CT scans. METHODS: Consecutive cases of spontaneous ICH were reviewed. Secondary causes were excluded. We measured ICH volume on the baseline and follow-up CT scans using the AxBxC/2 method. Multivariate analysis and logistic regression modeling were used. The primary outcome was the ICH volume on the baseline CT scan. Secondary outcomes included volume variation between the baseline and the first follow up CT scans and death. RESULTS: Of 303 subjects, 71 were taking a statin at the time of the ICH (23%). Statin users were significantly more likely to be younger, to have co-morbidities and take anticoagulant or anti-platelet medication. They also had a higher baseline ICH volume than non-statin users (median 31.2 [10, 82.1] ml vs 16 [4, 43.8] ml; p=0.006). Adjusting for possible confounders, statins remained associated with an increased ICH volume (p=0.007). There was a significant mean ICH volume progression between the first and second CT scans in statin users (+10.8 vs +0.9 ml; p=0.03; 95% CI: [-1, +22.6] [-2.5, +4.3]). No difference in mortality was seen between the two groups. CONCLUSION: Treatment with HMG-CoA reductase inhibitors may be a risk factor for increased ICH volume in spontaneous brain hemorrhages and could contribute to hemorrhage's volume progression.
机译：背景：一些研究表明低胆固醇血症与脑出血（ICH）之间存在关联。在SPARCL试验中，他汀类药物的使用增加了ICH的风险。我们检验了使用他汀类药物会影响自发性ICH量并有助于基线和后续CT扫描之间ICH量进展的假设。方法：回顾性分析自发性ICH的连续病例。次要原因被排除在外。我们使用AxBxC / 2方法在基线和后续CT扫描中测量了ICH体积。使用多变量分析和逻辑回归建模。主要结果是基线CT扫描上的ICH体积。次要结果包括基线与首次随访CT扫描之间的体积变化以及死亡。结果：在303名受试者中，有71名在ICH时服用他汀类药物（占23％）。服用他汀类药物的人很可能更年轻，有合并症并服用抗凝药或抗血小板药。与非他汀类药物使用者相比，他们的基线ICH量也更高（中位数31.2 [10，82.1] ml对16 [4，43.8] ml; p = 0.006）。调整可能的混杂因素后，他汀类药物仍与ICH量增加相关（p = 0.007）。他汀类药物使用者在第一次和第二次CT扫描之间有显着的平均ICH体积进展（+10.8 vs +0.9 ml; p = 0.03; 95％CI：[-1，+22.6] [-2.5，+4.3]）。两组间死亡率无差异。结论：HMG-CoA还原酶抑制剂治疗可能是自发性脑出血中ICH体积增加的危险因素，并且可能导致出血体积的进展。

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