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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Microembolic Signals in Patients with ^z>Systemic Lupus ErythematosusMahmoud Reza Azarpazhooh, Naghmeh Mokhber, Ellas Orouji, Brian R. Chambers, Mohammad Reza Hatef, Zahra Rezaieyazdi, Sima Sedighi,Mohsen Foroghipoor, Arash Velayati, Morteza Modares Gharavi
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Microembolic Signals in Patients with ^z>Systemic Lupus ErythematosusMahmoud Reza Azarpazhooh, Naghmeh Mokhber, Ellas Orouji, Brian R. Chambers, Mohammad Reza Hatef, Zahra Rezaieyazdi, Sima Sedighi,Mohsen Foroghipoor, Arash Velayati, Morteza Modares Gharavi

机译：ic z>系统性红斑狼疮患者的微栓塞信号Mahmoud Reza Azarpazhooh，Naghmeh Mokhber，Ellas Orouji，Brian R.Chambers，Mohammad Reza Hatef，Zahra Rezaieyazdi，Sima Sedighi，Mohsen Foroghipoor，Arash Velay

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Introduction: Central nervous system (CNS) involvement is a common and less understood aspect of systemic lupus erythematosus (SLE). Microembolic signals (MES) have been reported in SLE. We conducted a prospective study to evaluate the frequency of MES among patients with CNS involvement and those without. The main aim of the study is to clarify the pathophysiology of the CNS involvement in SLE. Methods and Materials: Sixty eight patients with a diagnosis of SLE (60 females, 8 males) participated in the study. Both middle cerebral arteries were monitored using transcranial Doppler for 60 min to detect MES. All cases underwent neurology and psychiatry assessments. Results: MES were detected in 7/68 patients (10.3%) with the mean number of 3.5 per hour. MES were significantly higher in patients with CNS involvement (6/24,25%) than those without (1/44,2.2%) (P=0.006). SLE disease activity index, duration of disease, plaque formation, intima-media thickness, and antiphospholipid antibodies were not associated with MES. MES were more frequent in patients receiving Aspirin and/or Warfarin (p=0.02). Conclusions: MES may be a predictor for CNS involvement in SLE patients at risk for neuropsychiatric syndromes. Cerebral embolism may be implicated in the pathophysiology of neuropsychiatric SLE.
机译：简介：参与中枢神经系统（CNS）是系统性红斑狼疮（SLE）的常见且鲜为人知的方面。在SLE中已经报道了微栓塞信号（MES）。我们进行了一项前瞻性研究，以评估中枢神经系统受累患者和无中枢神经系统受累患者的MES频率。该研究的主要目的是阐明中枢神经系统参与SLE的病理生理。方法和材料：六十八名患有SLE的患者（女性60例，男性8例）参加了研究。使用经颅多普勒监测两个大脑中动脉，持续60分钟以检测MES。所有病例均接受神经病学和精神病学评估。结果：在7/68例患者中检出MES（10.3％），平均每小时3.5例。中枢神经系统受累患者的MES显着高于无中枢神经系统的患者（6 / 24,25％）（1 / 44,2.2％）（P = 0.006）。 SLE疾病活动性指数，疾病持续时间，斑块形成，内膜中层厚度和抗磷脂抗体与MES无关。接受阿司匹林和/或华法林的患者中MES更为频繁（p = 0.02）。结论：MES可能是有神经精神病综合症风险的SLE患者中枢神经系统受累的预测指标。脑栓塞可能与神经精神病性SLE的病理生理有关。

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