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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Low grade glioma: a qualitative study of the wait and see approach.
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Low grade glioma: a qualitative study of the wait and see approach.

机译：低度神经胶质瘤：对观望方法的定性研究。

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BACKGROUND: There is no consensus on the best management of adults with presumed low grade glioma (LGG). Studies have suggested uncertainty and anxiety associated with a wait and see approach contribute to reduced quality of life. This study aims to explore the impact of a diagnosis of LGG, to address concerns regarding the uncertainty of the diagnosis and the role of wait and see from the patient's perspective. METHODS: Qualitative research methodology was used. A semi-structured interview was conducted with 24 patients with imaging evidence of LGG but no prior intervention. All patients had been followed for at least one year prior to interview. Verbatim transcripts were subjected to thematic analysis. RESULTS: The median age of participants was 47 (range 21-82) and the median duration of follow-up 37 months (range 12-156 months). Fifty percent presented with seizures. Five overarching themes emerged from the data; 1) patients experience initial devastation followed by acceptance and low anxiety; 2) absence of symptoms mitigates anxiety concerning the possibility of progression; 3) patients would prefer to defer surgery until there is progression or a change in their quality of life; 4) anxiety is reduced by trust in the physician; 5) quality of life is not affected by the diagnosis, as fear of morbidity from intervention is greater than the fear of uncertainty. CONCLUSIONS: The wait and see approach does not contribute to anxiety or reduction in quality of life in patients with LGG.
机译：背景：关于成人低度神经胶质瘤（LGG）的最佳治疗尚无共识。研究表明，观望方式带来的不确定性和焦虑感会导致生活质量下降。这项研究旨在探讨LGG诊断的影响，以解决有关诊断不确定性以及从患者角度观察和等待的作用的担忧。方法：采用定性研究方法。对24名具有LGG影像学证据但未进行干预的患者进行了半结构式访谈。所有患者在访谈前至少随访了一年。逐字记录进行主题分析。结果：参与者的中位年龄为47岁（范围为21-82岁），随访的中位时间为37个月（范围为12-156个月）。 50％出现癫痫发作。数据中出现了五个总体主题。 1）患者经历了最初的毁灭性后果，随后被接受并出现低焦虑感; 2）没有症状减轻了有关进展可能性的焦虑; 3）患者宁愿推迟手术，直到病情恶化或生活质量改变; 4）通过对医生的信任减轻焦虑; 5）生活质量不受诊断的影响，因为对干预的发病率的恐惧大于对不确定性的恐惧。结论：等待观察方法不会导致LGG患者焦虑或生活质量下降。

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