Hypoglossal nerve palsy is a rare cranial neuropathy with a broad differential diagnosis. Most etiologies typically present with other neurological or systemic sequelae(l). Thus, isolated hypoglossal nerve palsy presents a diagnostic challenge requiring a systematic investigative approach. We report of an interesting case of isolated unilateral hypoglossal nerve palsy following a mononucleosis infection. The investigative work-up, differential diagnosis, and management are discussed.
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