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Results of proton MRS studies in PVS and MCS patients.

机译:PVS和MCS患者质子MRS研究的结果。

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摘要

Proton magnetic resonance spectroscopy ('H-MRS) is useful in monitoring biochemical changes in metabolic, traumatic, infectious, and oncologic disorders of the brain. N-acetyl aspartate (NAA) content is a measure of neuronal integrity, choline (Cho) content mirrors membrane turnover, and creatine (Cre) relates to energy dependent systems. A decrement of NAA concentration has been interpreted as a sign of neuronal loss or dysfunction. To reduce intra and inter-subject variability in MRS measurements, peak area ratios are also computed for, NAA/Cre and NAA/Cho. MRS may thus improve the efficiency and sensitivity of MRI, especially for the detection of functional lesions that are not visible in conventional imaging sequences.
机译:质子磁共振波谱('H-MRS)可用于监测大脑的代谢性,创伤性,感染性和肿瘤性疾病的生化变化。 N-乙酰天门冬氨酸(NAA)含量是神经元完整性的量度,胆碱(Cho)含量反映了膜更新,而肌酸(Cre)与能量依赖性系统有关。 NAA浓度降低已被解释为神经元丧失或功能障碍的迹象。为了减少MRS测量中受试者内部和受试者之间的变异性,还计算了NAA / Cre和NAA / Cho的峰面积比。因此,MRS可以提高MRI的效率和灵敏度,特别是对于检测常规成像序列中不可见的功能性病变。

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