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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Cytokine gene polymorphisms and Parkinson's disease: a meta-analysis.
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Cytokine gene polymorphisms and Parkinson's disease: a meta-analysis.

机译：细胞因子基因多态性与帕金森氏病：荟萃分析。

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摘要

Cytokines, which are involved in immunological responses, play and important role in the development and progression of Parkinson's disease (PD). The functional polymorphisms identified in cytokine genes are thought to influence PD risk. However the findings of studies investigating the association between cytokine gene polymorphisms and PD risk are still controversial. Therefore, we conducted a meta-analysis, in order to investigate the potential associations between cytokine gene polymorphisms and PD. Studies of PD and cytokine polymorphisms were identified by searches of PubMed and PDGene. Pooled analyses were performed to assess the association between cytokine gene polymorphisms and PD. Our results indicated a positive association of TNFα -1031 CC genotype in overall analysis(CC vs. TT: OR=3.146; 95%CI: 1.631-6.070, p=0.008; CC vs. CT+TT: OR=3.187: 95%CI: 1.657-6.128,p=0.008), and an Asian subgroup, C variant(OR=1.328; 95%CI: 1.053-1.675, p=0.034) also conveyed an increased PD risk as well as CC genotype ( CC vs. TT: OR=3.207; 95%CI: 1.614-6.373, p=0.004; CC vs. CT+TT: OR=3.238; 95%CI: 1.636-6.410, p=0.004). A decreased risk for PD was associated with IL-6-174C allele (OR=0.761; 95%CI: 0.641-0.903, p=0.008) and IL-1RA VNTR 2 allele(OR=0.641; 95%CI: 0.456-0.826 p=0.004). For the polymorphisms of IL-1β C[-511]T, IL-1α C[-889]T , TNFα G[-308]A, and IL-10 G[-1082]A no significant association was found between the gene polymorphisms and PD risk. Our meta-analysis suggested that gene polymorphisms of TNFα -1031, IL-6-174 and IL-1RA VNTR may be associated with PD risk. However, more large well-designed studies will be necessary to validate our findings.
机译：参与免疫反应的细胞因子在帕金森氏病（PD）的发生和发展中起着重要作用。细胞因子基因中鉴定出的功能多态性被认为会影响PD风险。然而，研究细胞因子基因多态性与PD风险之间关系的研究结果仍存在争议。因此，我们进行了荟萃分析，以研究细胞因子基因多态性与PD之间的潜在关联。 PD和细胞因子多态性的研究是通过PubMed和PDGene的搜索确定的。进行汇总分析以评估细胞因子基因多态性与PD之间的关联。我们的结果表明TNFα-1031 CC基因型在总体分析中呈正相关（CC vs.TT：OR = 3.146; 95％CI：1.631-6.070，p = 0.008; CC vs.CT + TT：OR = 3.187：95％ CI：1.657-6.128，p = 0.008）和亚洲亚组C变体（OR = 1.328; 95％CI：1.053-1.675，p = 0.034）也增加了PD风险以及CC基因型（CC vs. CC）。 TT：OR ＝ 3.207; 95％CI：1.614-6.373，p ＝ 0.004; CC对CT + TT：OR ＝ 3.238; 95％CI：1.636-6.410，p ＝ 0.004）。 PD风险降低与IL-6-174C等位基因（OR = 0.761; 95％CI：0.641-0.903，p = 0.008）和IL-1RA VNTR 2等位基因（OR = 0.641; 95％CI：0.456-0.826）相关p = 0.004）。对于IL-1βC [-511] T，IL-1αC [-889] T，TNFαG [-308] A和IL-10 G [-1082] A的多态性，在该基因之间未发现显着关联多态性和PD风险。我们的荟萃分析表明，TNFα-1031，IL-6-174和IL-1RA VNTR的基因多态性可能与PD风险有关。但是，需要更多设计良好的大型研究来验证我们的发现。

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