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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Clinical fMRI: A pre-surgical test in patients with medically intractable epilepsy
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Clinical fMRI: A pre-surgical test in patients with medically intractable epilepsy

机译：临床功能磁共振成像：医学上难治性癫痫患者的术前测试

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摘要

Epilepsy is a common neurological disorder that affects between 0.5% - 1% of the general population. About 30% of the patients with localization-related epilepsy develop medication resistance and may benefit from surgery to improve their outcome. Anterior temporal lobectomy (ATL) is superior to medical therapy in patients with medically intractable temporal lobe epilepsy (TLE), which is the most common form of partial epilepsy. Favorable surgical outcome depends on proper selection of the patients on clinical basis, accurate localization of the epileptogenic focus with the electroencephalogram (EEG), and sparing of the important cognitive functions with the neuropsychological testing and other ancillary tests. Improvements in the magnetic resonance imaging (MRI) technology and its widespread availability have had a remarkable impact on the pre-surgical planning in epilepsy. High resolution anatomical MRI and quantitative analyses of the MRI findings are currently used to identify subtle epileptogenic lesions such as malformations of the cortical development and low grade tumors or focal brain atrophy that would have otherwise gone unnoticed.
机译：癫痫病是一种常见的神经系统疾病，会影响普通人群的0.5％-1％。大约30％的与定位有关的癫痫患者会产生药物耐药性，并且可能会受益于手术以改善其结局。对于患有顽固性颞叶癫痫（TLE）的患者，颞叶前切除术（ATL）优于药物治疗，后者是部分癫痫的最常见形式。良好的手术效果取决于临床上对患者的正确选择，脑电图（EEG）对癫痫病灶的准确定位以及神经心理学测试和其他辅助测试对重要认知功能的保留。磁共振成像（MRI）技术的改进及其广泛的可用性对癫痫的术前计划产生了重大影响。高分辨率解剖MRI和MRI发现的定量分析目前用于识别细微的癫痫病灶，例如皮质发育畸形，低度肿瘤或局灶性脑萎缩，否则这些现象将不会引起注意。

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