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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >A History of Multiple Sclerosis Investigations in Canada Between 1850 and 1950
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A History of Multiple Sclerosis Investigations in Canada Between 1850 and 1950

机译：1850至1950年间加拿大多发性硬化症调查的历史

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摘要

The medical profession's modern quandaries with Multiple Sclerosis (MS) largely began in 1849, with Friedrich von Frerichs' (1819-1885) early description of the clinical and pathological features of what he termed Hirnsklerose ("brain sclerosis"). This manuscript is an overview of the century of research (1850-1950) that followed the emergence of this clinical entity, with a focus on the hitherto under-explored English Canadian perspective. Using journal articles, reviews, and case studies, this historiographical paper reviews what may be some of the earliest recorded cases of MS in Canada, and outlines the diagnostic challenges that confronted early Canadian physicians in their encounters with MS. Early Canadian attempts to characterize the aetiology and epidemiology of MS and treat it are also discussed. These activities were influenced by developments in the field in Europe and the United States, and helped set the stage for the modern era of immunologic and therapeutic research on MS.
机译：医学界对多发性硬化症（MS）的现代认识很大程度上始于1849年，Friedrich von Frerichs（1819-1885）早期描述了他所说的Hirnsklerose（“脑硬化症”）的临床和病理特征。该手稿概述了该临床实体出现之后的一个世纪的研究（1850-1950年），并着重介绍了迄今尚未得到充分研究的加拿大英语观点。该史学论文使用期刊论文，评论和案例研究，回顾了加拿大最早记录的MS病例，并概述了加拿大早期医师在遇到MS时面临的诊断挑战。加拿大的早期尝试来表征MS的病因和流行病学，并对其进行治疗。这些活动受到欧洲和美国领域发展的影响，并为现代MS免疫学和治疗学研究奠定了基础。

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