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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >D-Serine in Neurobiology: CNS Neurotransmission and Neuromodulation
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D-Serine in Neurobiology: CNS Neurotransmission and Neuromodulation

机译：神经生物学中的D-丝氨酸：中枢神经系统神经传递和神经调节

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摘要

Homochirality is fundamental for life. L-Amino acids are exclusively used as substrates for the polymerization and formation of peptides and proteins in living systems. However, D- amino acids were recently detected in various living organisms, including mammals. Of these D-amino acids, D-serine has been most extensively studied. D-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl- D-aspartate receptor (NMDAr). D-Serine binds with high affinity to a co-agonist site at the NMDAr and, along with glutamate, mediates several vital physiological and pathological processes, including NMDAr transmission, synaptic plasticity and neurotoxicity. Therefore, a key role for D-serine as a determinant of NMDAr mediated neurotransmission in mammalian CNS has been suggested. In this context, we review the known functions of D-serine in human physiology, such as CNS development, and pathology, such as neuro-psychiatric and neurodegenerative diseases related to NMDAr dysfunction.
机译：同质性是生命的基础。 L-氨基酸专门用作在生命系统中聚合和形成肽和蛋白质的底物。但是，最近在包括哺乳动物在内的各种生物中检测到了D-氨基酸。在这些D-氨基酸中，对D-丝氨酸的研究最为广泛。发现D-丝氨酸通过与N-甲基-D-天冬氨酸受体（NMDAr）结合而在人中枢神经系统（CNS）中作为神经递质发挥重要作用。 D-丝氨酸以高亲和力结合到NMDAr的共激动剂位点，并与谷氨酸一起介导几个重要的生理和病理过程，包括NMDAr传递，突触可塑性和神经毒性。因此，已经提出了D-丝氨酸作为哺乳动物CNS中NMDAr介导的神经传递的决定因素的关键作用。在这种情况下，我们回顾了D-丝氨酸在人体生理学中的已知功能，例如中枢神经系统的发育，以及病理学，例如与NMDAr功能障碍有关的神经精神疾病和神经退行性疾病。

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