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Silas Weir Mitchell on Epilepsy Therapy in the Late 19th to Early 20th Centuries

机译:西拉斯·威尔·米切尔(Silas Weir Mitchell)在19世纪末至20世纪初对癫痫疗法的研究

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摘要

Silas Weir Mitchell (1829-1914), one of the fathers of American neurology, is well known for many contributions to neurology. However, his efforts in epilepsy are overshadowed by his other accomplishments. Mitchell introduced a new bromide preparation, lithium bromide, as a viable therapy. His most widely accepted contribution to the field was the introduction of inhaled amyl nitrite for early termination of seizures accompanied by an appropriate aura. Despite the prevalent views on lifestyle modification as a treatment for epilepsy during this time period, as well as Mitchell's own development of the "rest cure" for certain disease states, he was not a proponent of these types of interventions for epilepsy, nor did he support interventions focused on other organ systems, such as abdominal or gynecologic surgery. Mitchell had distinct opinions on the treatment of epilepsy, and helped to advance its therapeutics during his career.
机译:Silas Weir Mitchell(1829-1914),美国神经病学之父之一,以对神经病学的许多贡献而闻名。然而,他在癫痫方面的努力被他的其他成就所掩盖。米切尔(Mitchell)推出了一种新的溴化物制剂溴化锂,作为一种可行的疗法。他对该领域的最广泛接受的贡献是引入了吸入亚硝酸戊酯,以尽早终止癫痫发作并伴有适当的先兆。尽管在这段时间里人们普遍认为改变生活方式可以治疗癫痫病,以及米切尔自己开发的针对某些疾病的“休息疗法”,但他并不支持这些类型的癫痫病干预措施,他也不支持支持针对其他器官系统的干预措施,例如腹部或妇科手术。米切尔对癫痫的治疗有不同的见解,并在他的职业生涯中帮助推进了癫痫的治疗。

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