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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Evaluation of Brainstem Involvement in Multiple Sclerosis
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Evaluation of Brainstem Involvement in Multiple Sclerosis

机译：脑干多发性硬化症的评估。

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Background/Aims: The aim of the present study was to determine the optimum method to detect brainstem lesions in patients with Multiple Sclerosis (MS). Methods: 72 patients with the diagnosis of relapsing-remitting MS were prospectively included. Brainstem functional system score (BSFS) (part of the expanded disability status scale (EDSS) evaluating brainstem symptomatology) was calculated. Magnetic resonance imaging (MRI) was performed on 1.5T and T1, T2, PD and fluid-attenuated inversion recovery (FLAIR) sequences were analyzed for presence of brainstem lesions. Auditory evoked potentials (AEP) and ocular and cervical vestibular evoked myogenic potentials (oVEMP and cVEMP) were performed according to the standardized protocol. Results: From 72 patients, 18 (25%) had clinical involvement of the brainstem. MRI showed brainstem involvement in 29 (40%) patients. Of the neurophysiological tests, AEP showed pathological result in 16 (22%) patients, oVEMP in 36 (50%) patients, cVEMP in 18 (25%) patients. and VEMP (combination of oVEMP and cVEMP) in 45 (63%) patients. VEMP detected brainstem lesions in higher percentage than clinical examination, MRI and AEP, which was statistically significant (< 0.0001, 0.012 and < 0.0001, respectively). Conclusions: Results of the present study have shown that VEMPs are the optimal method to detect brainstem lesions in multiple sclerosis and that they detect them significantly better than clinical examination. AEP or MRI.
机译：背景/目的：本研究的目的是确定检测多发性硬化症（MS）患者脑干病变的最佳方法。方法：前瞻性纳入72例诊断为复发-缓解型MS的患者。计算了脑干功能系统评分（BSFS）（评估脑干症状的扩展的残疾状态量表（EDSS）的一部分）。在1.5T上进行磁共振成像（MRI），并分析T1，T2，PD和减液反转恢复（FLAIR）序列是否存在脑干病变。听觉诱发电位（AEP）以及眼和颈前庭诱发的肌源性电位（oVEMP和cVEMP）根据标准化方案进行。结果：在72例患者中，有18例（25％）有脑干受累。 MRI显示29例（40％）患者脑干受累。在神经生理学测试中，AEP显示16例（22％）患者的病理结果，oVEMP出现36例（50％）的患者，cVEMP出现18例（25％）的患者。 45例（63％）患者接受VEMP和oVEMP和cVEMP联合治疗。 VEMP检测到的脑干病变的比例高于临床检查，MRI和AEP，具有统计学意义（分别为<0.0001、0.012和<0.0001）。结论：本研究结果表明，VEMPs是检测多发性硬化症脑干病变的最佳方法，并且其检测效果明显优于临床检查。 AEP或MRI。

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