• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Are Patients with Limb and Head Tremor a Clinically Distinct Subtype of Essential Tremor?
【24h】

Are Patients with Limb and Head Tremor a Clinically Distinct Subtype of Essential Tremor?

机译：肢体和头部震颤患者是否是原发性震颤的临床上不同的亚型？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Essential tremor (ET) is the most common tremor disorder in adults. In addition to upper limbs, the tremor in ET may also involve head, jaw, voice, tongue, and trunk. Though head tremor (HT) is commonly present in patients with ET, large comparative studies of ET patients with HT (HT+) and without HT (HT-) are few. Methods: To determine whether ET with HT is a distinct clinical subtype by comparing ET patients with and without HT, a chart review of 234 consecutive patients with ET attending the neurology clinics of the National Institute of Mental Health and Neurosciences, India, was done. A movement disorder specialist confirmed the diagnosis of ET in all patients using the National Institutes of Health collaborative genetic criteria. Results: HT was present in 44.4% of the patients. Comparison between HT+ and HT-showed that the HT+ group patients: (1) were older, (2) had later onset of tremor, (3) had unimodal distribution of age at onset with a single peak in the fifth decade, (4) had more frequent voice tremor, and (5) were more likely to have mild cervical dystonia. HT was part of presenting symptoms in nearly two thirds of the ET patients and in the rest it was detected during clinical examination. Conclusions: Several demographic and clinical variables suggest that ET patients with HT have a distinct clinical phenotype.
机译：背景：原发性震颤（ET）是成年人中最常见的震颤疾病。除上肢外，ET中的震颤也可能涉及头部，下颌，声音，舌头和躯干。尽管在ET患者中普遍存在头部震颤（HT），但对有HT（HT +）和无HT（HT-）的ET患者进行的大型比较研究很少。方法：通过比较有和没有HT的ET患者来确定有HT的ET是否是不同的临床亚型，对印度国家心理健康和神经科学研究所神经病学诊所的234例连续的ET患者进行了图表回顾。运动障碍专家使用美国国立卫生研究院合作遗传标准确认了所有患者的ET诊断。结果：44.4％的患者存在HT。 HT +和HT +的比较显示，HT +组患者：（1）年龄较大，（2）震颤发作较晚，（3）发病年龄单峰分布，在第五个十年中有一个高峰，（4）患有更频繁的声音震颤，并且（5）患轻度宫颈肌张力障碍的可能性更高。 HT是近三分之二的ET患者出现症状的一部分，其余患者在临床检查中被发现。结论：几个人口统计学和临床​​变量表明，ET HT患者具有独特的临床表型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号