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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Dynamic Decomposition of Motion in Essential and Parkinsonian Tremor
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Dynamic Decomposition of Motion in Essential and Parkinsonian Tremor

机译：在原发性和帕金森氏震颤中运动的动态分解

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Background: Treatment options for essential (ET) and Parkinson disease (PD) tremor are suboptimal, with significant side effects. Botulinum toxin type A (BoNT A) is successfully used in management of various focal movement disorders but is not widely used for tremor. Method: This study examines complexity of wrist tremor in terms of involvement of its three anatomical degrees of freedom (DOF) in two common situations of rest and posture. The study examines tremor in 11 ET and 17 PD participants by kinematic decomposition of motion in 3-DOF. Results: Tremor decomposition showed the motion involved more than one DOF (<70% contribution in one DOF) in most ET (rest: 100%, posture: 64%) and PD (rest: 77%, posture: 77%) patients. Task variation resulted in change in both amplitude and composition in ET, but not in PD. Amplitude significantly increased from rest to posture in ET. Directional bias was observed at the wrist for ET (pronation), and PD (extension, ulnar deviation, pronation). Average agreement between clinical visual and kinematic selection of muscles was 55% across all subjects. Conclusion: This study shows the complexity of tremor and the difficulty in visual judgment of tremor, which may be key to the success of targeted focal treatments such as BoNT A.
机译：背景：原发性（ET）和帕金森氏病（PD）震颤的治疗选择欠佳，且有明显的副作用。 A型肉毒毒素（BoNT A）已成功用于各种局灶性运动障碍的治疗，但并未广泛用于震颤。方法：本研究通过在两种常见的休息和姿势情况下，其三个解剖学自由度（DOF）的参与来检查腕部震颤的复杂性。该研究通过运动在3自由度中的运动学分解来检查11名ET和17名PD参与者的震颤。结果：震颤分解表明，在大多数ET（休息：100％，姿势：64％）和PD（休息：77％，姿势：77％）患者中，运动涉及一个以上DOF（在一个DOF中的贡献<70％）。任务变化导致ET的幅度和成分发生变化，而PD则没有。 ET中从静止到姿势的幅度明显增加。在腕部观察到ET（前旋）和PD（伸展，尺骨偏斜，前旋）的方向性偏向。在所有受试者中，肌肉的临床视觉选择和运动学选择之间的平均一致性为55％。结论：本研究显示了震颤的复杂性和震颤视觉判断的困难，这可能是靶向性靶向治疗（如BoNT A）成功的关键。

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