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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Transient hemichorea/hemiballismus associated with new onset hyperglycemia.
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Transient hemichorea/hemiballismus associated with new onset hyperglycemia.

机译：与新发高血糖症相关的短暂性偏瘫/半球错病。

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摘要

OBJECTIVE: To describe three patients suffering from transient hemichorea/hemiballismus associated with hyperglycemia, review previous reports and propose a possible pathophysiological explanation for this phenomenon. RESULTS: Our original cases and previously reported ones reveal a uniform syndrome: mostly female patients (F/M ratio of 11/2), 50-80 years old, usually with no previous history of diabetes mellitus (9/13), develop choreic or ballistic movements on one side of the body over a period of hours. Serum glucose levels are elevated. In most of the patients, a lowering of the blood sugar level reverses the movement disorder within 24-48 hours. CONCLUSIONS: We believe that the combination of a recent or old striatal lesion (causing increased inhibition of the subthalamic nucleus) and hyperglycemia (causing decreased GABAergic inhibition of the thalamus) may be responsible for the appearance of this unilateral hyperkinetic movement disorder. Undiagnosed diabetes mellitus should always be suspected in patients who develop hemiballistic or hemichoreic movements. When hyperglycemia is detected and corrected, the movement disorder usually resolves within two days and may not require symptomatic therapy with dopamine receptor antagonists.
机译：目的：描述三例伴有高血糖的短暂性偏瘫/半球性支气管炎的患者，回顾以前的报道并为这种现象提出可能的病理生理学解释。结果：我们的原始病例和先前报道的病例均显示出一种统一的综合征：多数为女性（F / M比为11/2），年龄为50-80岁，通常没有糖尿病史（9/13），发展为舞蹈性数小时内身体一侧的弹道运动。血清葡萄糖水平升高。在大多数患者中，降低血糖水平可在24-48小时内逆转运动障碍。结论：我们认为，近期或较旧的纹状体病变（导致对丘脑下核的抑制作用增强）和高血糖症（导致对丘脑的GABA能抑制作用降低）的结合可能是导致这种单侧运动亢进性疾病的原因。出现半球或偏瘫运动的患者应始终怀疑未诊断的糖尿病。一旦发现并纠正了高血糖症，运动障碍通常会在两天内消退，可能不需要多巴胺受体拮抗剂的对症治疗。

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