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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Neurocognitive symptoms and impairment in an HIV community clinic.
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Neurocognitive symptoms and impairment in an HIV community clinic.

机译：HIV社区诊所的神经认知症状和损伤。

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BACKGROUND: Neurocognitive impairment is a frequent complication of HIV infection and heralds a poor survival prognosis. With the availability of highly active antiretroviral therapy (HAART), survival times for HIV-infected patients have markedly increased although the effects of HAART on the prevalence of neurocognitive impairment remain uncertain. OBJECTIVE: To determine the relationship between self-reported neurocognitive symptoms and neuropsychological (NP) performance together with the impact of HAART among HIV-infected patients. METHODS: A cross-sectional study was performed in which patients without previously documented neurocognitive impairment attending an HIV community clinic were questioned about neurocognitive symptoms and a NP test battery was administered. RESULTS: Of the eighty-three patients examined, neurocognitive symptoms were reported by 34% of patients and were associated with a shorter duration of HAART and higher viral loads. Patients reporting neurocognitive symptoms were also more likely to exhibit impaired NP performance (p<0.005) with NP impairment being detected in 46% of all patients examined (12% with HIV-associated dementia). Neuropsychological impairment was directly correlated with age (p<0.001), plasma viral load (p<0.005) and inversely correlated with the number of prescribed antiretroviral drugs (p<0.01). CONCLUSIONS: These results suggest that neurocognitive symptoms are predictive of impaired NP performance and that NP impairment remains a frequent finding among older patients with higher viral loads. An increased number of antiretroviral drugs may be neuroprotective.
机译：背景：神经认知障碍是艾滋病毒感染的常见并发症，预示着不良的预后。随着高活性抗逆转录病毒疗法（HAART）的使用，HIV感染患者的生存时间显着增加，尽管HAART对神经认知障碍患病率的影响尚不确定。目的：确定自我报告的神经认知症状与神经心理（NP）表现之间的关系，以及HAART对HIV感染患者的影响。方法：进行了一项横断面研究，在该研究中，对以前未到HIV社区门诊就诊的神经认知功能受损的患者询问神经认知症状，并进行了NP测试。结果：在检查的83例患者中，有34％的患者报告了神经认知症状，并伴有较短的HAART持续时间和较高的病毒载量。报告神经认知症状的患者也更有可能表现出NP功能受损（p <0.005），在所有接受检查的患者中有46％（与HIV相关的痴呆症占12％）被检测到NP受损。神经心理障碍与年龄（p <0.001），血浆病毒载量（p <0.005）直接相关，与处方抗逆转录病毒药物的数量呈负相关（p <0.01）。结论：这些结果表明，神经认知症状可预测NP性能受损，而NP损伤仍是病毒载量较高的老年患者的常见发现。越来越多的抗逆转录病毒药物可能具有神经保护作用。

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