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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Modafinil in endozepine stupor. A case report.
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Modafinil in endozepine stupor. A case report.

机译：莫达非尼在内啡肽pine中。病例报告。

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摘要

BACKGROUND: Endozepine-4 stupor is a rare disorder. It presents with recurrent episodes of stupor and coma. Endozepine-4 levels are elevated during an attack with electroencephalogram showing fast activity during the ictal phase. There is no specific treatment and various drugs have been tried without long-term benefit. METHOD: We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor. RESULTS: The vigilance promoting drug modafinil prevented recurrent episodes of stupor and coma in this patient at a dose of 200 mg/day for a period of six months. Upon withdrawal of the drug, the patient experienced recurrent episodes and on reinstitution of modafinil she has remained asymptomatic in the following one year.
机译：背景：Endozepine-4木僵是一种罕见的疾病。表现为反复发作的木僵和昏迷。脑电图发作时，内啡肽4水平升高，脑电图显示在发作期快速活动。没有特定的治疗方法，尝试了多种药物，没有长期的益处。方法：我们使用提高警惕的药物莫达非尼预防出现内啡肽昏迷的情况。结果：提高警惕的药物莫达非尼在200毫克/天的剂量下预防了该患者木僵和昏迷的复发发作，持续了六个月。停药后，患者反复发作，并在莫达非尼恢复治疗后一年内仍无症状。

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