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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Indicators of functional status for primary malignant brain tumour patients.
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Indicators of functional status for primary malignant brain tumour patients.

机译：原发性恶性脑肿瘤患者的功能状态指标。

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BACKGROUND: We compared the functional status and survival time of patients with malignant gliomas. METHODS: This retrospective review included 143 patients diagnosed with malignant gliomas. Patients were grouped according to histopathological diagnosis. To measure functional status, patients were assigned a Karnofksy performance status (KPS) score at the time of presentation and at one, three, six, nine, 12 months and yearly intervals thereafter. Data were analyzed using descriptive methods as well as Kruskal-Wallis tests, Chi-square tests, Log-Rank tests and Cox's proportional hazards modeling. RESULTS: Eighty-four patients were male. The median age of patients was 63 years. One hundred and seven patients had a histopathological diagnosis of glioblastoma multiforme, 23 of anaplastic astrocytoma and 13 of anaplastic oligodendroglioma. Twenty-nine patients received aggressive multimodal treatment, 83 received intermediate treatment and the remaining 31 patients received conservative therapy. Significant treatment complications occurred in 33% of patients including four post-operative deaths. The anaplastic oligodendroglioma group had lower mortality and maintained better KPS scores over time, as did patients receiving full treatment. The most significant prognostic factors for functional status included age, pretreatment KPS, and type of treatment received. The most significant factors associated with time until death included age, severity of comorbidities, pretreatment KPS, presence of confusion, histopathological diagnosis and type of treatment received. CONCLUSION: In patients with malignant gliomas, younger age, better functional status at presentation and aggressive multimodal treatment were associated with improved longer-term functional status and survival. Confirmation of the effect of multimodal treatment on patient functional status would require a randomised controlled clinical trial.
机译：背景：我们比较了恶性神经胶质瘤患者的功能状态和生存时间。方法：该回顾性研究纳入了143例诊断为恶性神经胶质瘤的患者。根据组织病理学诊断将患者分组。为了测量功能状态，患者在就诊时以及之后的1、3、6、9、12个月和每年的间隔中被分配了卡诺夫斯基表现状态（KPS）评分。使用描述性方法以及Kruskal-Wallis检验，卡方检验，Log-Rank检验和Cox比例风险建模对数据进行了分析。结果：84例患者为男性。患者的中位年龄为63岁。 107例患者的组织病理学诊断为多形性胶质母细胞瘤，间变性星形细胞瘤23例，间变性少突胶质细胞瘤13例。 29例患者接受了积极的多式联运治疗，83例接受了中间治疗，其余31例接受了保守治疗。 33％的患者发生了严重的治疗并发症，包括四例术后死亡。间变性少突胶质细胞瘤组的死亡率较低，并且随着时间的推移，其KPS得分保持较高，接受全面治疗的患者也是如此。功能状态最重要的预后因素包括年龄，治疗前KPS和接受的治疗类型。与死亡时间相关的最重要因素包括年龄，合并症的严重程度，治疗前的KPS，出现混淆，组织病理学诊断和所接受的治疗类型。结论：在恶性神经胶质瘤患者中，年龄较小，就诊时功能状态改善和积极的多式联运治疗与长期功能状态和生存期改善有关。要确认多模式治疗对患者功能状态的影响，需要进行随机对照临床试验。

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