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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Nipah encephalitis outbreak in Malaysia, clinical features in patients from Seremban.
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Nipah encephalitis outbreak in Malaysia, clinical features in patients from Seremban.

机译：马来西亚Nipah脑炎暴发，芙蓉患者的临床特征。

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摘要

BACKGROUND: An outbreak of viral encephalitis occurred among pig industry workers in Malaysia in September 1998 to April 1999. The encephalitis was attributed to a new paramyxovirus, Nipah virus. This is a description of the clinical features of 103 patients treated in the Seremban Hospital with characterization of the prognostic factors. METHODS: Clinical case records and laboratory investigations were reviewed. The case definition was: patients from the outbreak area, direct contact or in close proximity with pigs, clinical or CSF features of encephalitis. RESULTS: The mean age was 38 years, 89% were male, 58% were ethnic Chinese, 78% were pig farm owners or hired workers. The mean incubation period was 10 days. The patients typically presented with nonspecific systemic symptoms of fever, headache, myalgia and sore throat. Seizures and focal neurological signs were seen in 16% and 5% respectively. In the more severe cases, this was followed by drowsiness and deteriorating consciousness requiring ventilation in 61%. Autonomic disturbances and myoclonic jerks were common features. The mortality was high at 41%. Systolic hypertension, tachycardia and high fever were associated with poor outcome. On the other hand, 40% recovered fully. As for the other 19%, the residual neurological signs were mostly mild. CONCLUSION: Nipah virus caused an encephalitis illness with short incubation period and high mortality. The prognosis for the survivors was good.
机译：背景：1998年9月至1999年4月，马来西亚养猪业工人中爆发了病毒性脑炎。该脑炎归因于一种新型副粘病毒Nipah病毒。这是对芙蓉医院治疗的103例患者的临床特征的描述，并对预后因素进行了描述。方法：回顾临床病例记录和实验室检查。病例定义为：来自暴发地区，直接接触猪或与猪密切接触的患者，脑炎的临床或CSF特征。结果：平均年龄为38岁，男性占89％，华裔占58％，养猪场所有者或雇工占78％。平均潜伏期为10天。患者通常表现出发烧，头痛，肌痛和喉咙痛的非特异性全身症状。癫痫发作和局灶性神经症状分别占16％和5％。在更严重的情况下，其次是嗜睡和意识下降，需要通气的占61％。自主神经紊乱和肌阵挛性抽搐是常见的特征。死亡率高达41％。收缩期高血压，心动过速和高烧与不良预后相关。另一方面，有40％的人完全康复。至于其他19％，残留的神经系统症状大多是轻度的。结论：尼帕病毒引起脑炎疾病，潜伏期短，死亡率高。幸存者的预后良好。

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