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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Ifosfamide encephalopathy and nonconvulsive status epilepticus.
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Ifosfamide encephalopathy and nonconvulsive status epilepticus.

机译：异环磷酰胺脑病和非惊厥性癫痫持续状态。

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BACKGROUND: Ifosfamide (IFX), an alkylating agent and isomer of cyclophosphamide, is used as a single agent or a component of multi-agent chemotherapy in the treatment of ovarian, testicular, head and neck cancers, sarcomas and lymphomas. Encephalopathy is manifested by cerebellar ataxia, confusional state, complex visual hallucinations, extrapyramidal signs, seizures, and mutism. CASE REPORTS: We report two patients with non-Hodgkin's lymphoma presenting with mutism and confusional state after IFX infusion. Nonconvulsive status epilepticus (NCSE) as the cause of confusion was diagnosed on the basis of EEG pattern and the apparent improvement following intravenous administration of diazepam. CONCLUSIONS: Electroencephalogram abnormalities during IFX treatment have been described but recordings are only available in six cases. In three of them, paroxysmal alterations warranted the diagnosis of NCSE; however, most cases of IFX encephalopathy might have associated NCSE.
机译：背景：异环磷酰胺（IFX）是环磷酰胺的烷基化剂和异构体，在卵巢癌，睾丸癌，头颈癌，肉瘤和淋巴瘤的治疗中，被用作单药或多药化疗的组成部分。脑病表现为小脑性共济失调，精神错乱，视觉幻觉复杂，锥体外系体征，癫痫发作和默症。病例报告：我们报告了两名非霍奇金淋巴瘤患者，在IFX输注后出现变和混乱状态。根据脑电图模式和地西epa静脉注射后的明显改善，诊断为非惊厥性癫痫持续状态（NCSE）。结论：已经描述了IFX治疗期间的脑电图异常，但仅在6例病例中有记录。在其中三例中，阵发性改变值得诊断为NCSE。但是，大多数IFX脑病病例可能伴有NCSE。

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