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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Multiple sclerosis in its European matrix: some aspects of history, mechanisms and treatment.
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Multiple sclerosis in its European matrix: some aspects of history, mechanisms and treatment.

机译：欧洲多发性硬化症：历史，机制和治疗的某些方面。

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摘要

Susceptibility to multiple sclerosis is influenced by several genes which are relatively common in populations of European origin. Their precise identification is currently being intensively investigated. The pathophysiology of the main clinical features is better understood. Relapse results from abnormalities of conduction to which both demyelination and inflammation contribute. At the membrane level, remission depends on the formation of new sodium channels which restore conduction even in persistently demyelinated axons. Remyelination presumably contributes and synaptic reorganisation may also do so. Axonal degeneration contributes to irrecoverable deficit and progression of disability. These observations suggest new therapeutic strategies. The management of multiple sclerosis needs to be improved. Progress requires an ethically based partnership between patients, whose needs are paramount, the research and caring communities and the pharmaceutical industry.
机译：多发性硬化症的易感性受到欧洲起源人群中相对常见的几种基因的影响。他们的精确识别目前正在深入研究中。主要临床特征的病理生理学已被更好地理解。复发归因于脱髓鞘和炎症均引起的传导异常。在膜水平上，缓解取决于新的钠通道的形成，即使在持续脱髓鞘的轴突中也能恢复传导。髓鞘再生可能起了作用，突触重组也可能起了作用。轴突变性导致无法弥补的缺陷和残疾的发展。这些观察结果提出了新的治疗策略。多发性硬化症的管理需要改善。要取得进步，就需要患者，研究和关怀社区以及制药行业之间的基于伦理的伙伴关系。

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