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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Structural abnormalities are similar in familial and nonfamilial mesial temporal lobe epilepsy.
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Structural abnormalities are similar in familial and nonfamilial mesial temporal lobe epilepsy.

机译：家族性和非家族性颞叶颞叶癫痫的结构异常相似。

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摘要

BACKGROUND/OBJECTIVE: Diffuse temporal lobe abnormalities can be observed on MRI of patients with mesial temporal lobe epilepsy (MTLE). Our objective was to perform qualitative and quantitative analyses of temporal lobe structures in patients with familial MTLE (FMTLE) and nonfamilial MTLE. METHODS: Two groups of patients were ascertained: 67 FMTLE patients (14 with refractory seizures) and 30 patients with nonfamilial refractory MTLE. We performed qualitative analyses of MRI (with multiplanar reconstruction) and volumes of hippocampi and anterior temporal lobes in all patients, and in a normal control group of 23 individuals. We used the Chi-square test and ANOVA for statistical analyses. RESULTS: We identified anterior temporal lobe abnormalities by visual analysis in only 4% of FMTLE patients and atrophy of the anterior temporal lobe by volumetric analysis in 19%. In the group of nonfamilial MTLE patients we found anterior temporal lobe abnormalities by visual analysis in 17% of patients and anterior temporal lobe atrophy in 13%. Hippocampal atrophy was present in 90% of FMTLE and in 83% of nonfamilial MTLE. No signs of cortical dysplasia were observed. CONCLUSION: Anterior temporal lobe atrophy and other abnormalities outside the mesial portion of temporal lobes were infrequent in both familial and nonfamilial MTLE patients. Despite the genetic basis, hippocampal atrophy in FMTLE is not associated with other abnormalities outside the mesial temporal regions.
机译：背景/目的：弥散性颞叶异常可在MRI中观察到颞叶内侧癫痫（MTLE）患者。我们的目标是对家族性MTLE（FMTLE）和非家族性MTLE患者的颞叶结构进行定性和定量分析。方法：确定两组患者：67例FMTLE患者（14例难治性癫痫发作）和30例非家族性难治性MTLE患者。我们对23例正常对照组的所有患者进行了MRI（多平面重建）以及海马和颞叶前叶体积的定性分析。我们使用卡方检验和方差分析进行统计分析。结果：我们仅通过视觉分析在4％的FMTLE患者中发现了颞叶前部异常，而通过体积分析在19％的患者中发现了颞叶前部萎缩。在非家族性MTLE患者组中，通过视觉分析发现前颞叶异常的患者为17％，前颞叶萎缩的患者为13％。在90％的FMTLE和83％的非家族性MTLE中存在海马萎缩。没有观察到皮质发育异常的迹象。结论：家族性和非家族性MTLE患者的前颞叶萎缩和颞叶中部以外的其他异常很少见。尽管有遗传基础，但FMTLE中的海马萎缩与颞内侧区以外的其他异常无关。

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