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首页> 外文期刊>The Canadian journal of urology >Clinically atypical seminomas with yolk sac tumor features.
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Clinically atypical seminomas with yolk sac tumor features.

机译：具有卵黄囊肿瘤特征的临床非典型精原细胞瘤。

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A small subset of young men die from seminoma. Studying these high risk, clinically atypical seminomas (CASs)-aggressive tumors with visceral metastases and chemotherapy resistance-may provide clues to the nature of drug resistance and the origin of testicular cancers. We explored the possibility that these seminomas are a unique clinical and biologic entity with intrinsic yolk sac tumor (YST) features.We assayed available archived tissue samples (n = 22) for chemotherapy-resistance markers found in YSTs. Specifically, we analyzed tissues and clinical histories from patients with CASs (those who had visceral metastases and recurrent disease), classical seminomas, and mixed germ-cell tumors containing YST. By using immunohistochemical testing, we evaluated the expression of bone morphogenetic protein 2, alpha fetoprotein, and glutathione S-transferase (pi) [GST (pi)].GST (pi) expression significantly predicted for overall survival (p = .036). In addition, according to the results of GST (pi) immunohistochemical staining, the CASs appeared to resemble YSTs more than they did classical seminomas (p = 0.043). Less-advanced tumors, both those that expressed GST (pi) and those that were negative for GST (pi), were more amenable to local therapies, and the patients who had those tumors had better clinical outcomes.Results from this exploratory study suggest that certain CASs that express GST (pi) are more similar to YST than they are to classical seminomas, and that GST (pi) expression may be able to be used as a prognosticator of disease-specific survival. Such CASs thus may have a unique biologic origin that differs from that of classical seminomas. Additional studies are needed to determine the natural history and therapeutic implications of these CASs.
机译：一小部分年轻人死于精原细胞瘤。研究这些高风险，临床上不典型的精原细胞瘤（CASs）-具有内脏转移和化疗耐药性的侵袭性肿瘤-可能为耐药性的性质和睾丸癌的起源提供线索。我们探讨了这些精原细胞瘤是具有固有卵黄囊肿瘤（YST）特征的独特临床和生物学实体的可能性。我们对可用的存档组织样本（n = 22）中的YSTs中发现的化疗耐药性标志物进行了分析。具体而言，我们分析了CASs（患有内脏转移和复发性疾病的患者），经典精原细胞瘤和含有YST的混合生殖细胞肿瘤患者的组织和临床历史。通过免疫组织化学测试，我们评估了骨形态发生蛋白2，甲胎蛋白和谷胱甘肽S-转移酶（pi）[GST（pi）]的表达。GST（pi）的表达显着预测了总生存期（p = .036）。此外，根据GST（pi）免疫组织化学染色的结果，CAS比传统的精原细胞瘤更像YST（p = 0.043）。表达GST（pi）和GST阴性（pi）的晚期肿瘤较容易接受局部治疗，并且患有这些肿瘤的患者具有更好的临床结局。某些表达GST（pi）的CAS与经典的精原细胞瘤相比与YST更相似，并且GST（pi）的表达可以用作疾病特异性生存的预后指标。因此，此类CAS可能具有不同于经典精原细胞瘤的独特生物学起源。需要进行其他研究以确定这些CAS的自然病史和治疗意义。

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