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首页> 外文期刊>The Canadian journal of urology >Vitamin D and benign prostatic hyperplasia -- a review.
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Vitamin D and benign prostatic hyperplasia -- a review.

机译：维生素D与良性前列腺增生-综述。

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Benign prostatic hyperplasia (BPH) is a more common form of lower urinary tract symptoms (LUTS). BPH is due to the excessive growth of both stromal and epithelial cells of the prostate. Fifty percent of men over the age of 50 will have this disease, along with the probability that 90% of men at the age of 80 will have an enlarged prostate. The prevalence of vitamin D deficiency in the male urological population may represent a connection between BPH and vitamin D.This review is geared to provide the most relevant data on the correlation between vitamin D and BPH. A comprehensive review was conducted on all studies on the specific topic and compiled into a complete article.Data suggests that vitamin D has an inhibitory effect on the RhoA/ROCK pathway, along with cyclooxygenase-2 expression and prostaglandin E2 production in BPH stromal cells. Increasing intake of vitamin D from diet and supplements has shown a correlation with decreased BPH prevalence. Vitamin D analogues of up to 6000 IU/day have shown to decrease prostate volume in BPH patients. Pre-clinical trials have shown vitamin D to not only decrease BPH cell and prostate cell proliferation alone, but also when induced by known growth promoting molecules such as IL-8, Des (1-3) IGF-1, testosterone and dihydrotestosterone. Among all the studies there has not been any side effects or negative implications with increased vitamin D intake.The impact of vitamin D on prostate volume and BPH has shown promising results, thus proposing further studies on vitamin D and BPH be conducted.
机译：良性前列腺增生（BPH）是下尿路症状（LUTS）的一种较常见形式。 BPH是由于前列腺基质细胞和上皮细胞过度生长所致。 50岁以上的男性中有50％患有这种疾病，而80岁以上的男性中90％的男性前列腺会增大。男性泌尿科人群中维生素D缺乏症的流行可能表示BPH与维生素D之间存在联系。本综述旨在提供有关维生素D与BPH之间相关性的最相关数据。对该主题的所有研究均进行了全面的综述，并整理成完整的文章。数据表明，维生素D对Bho基质细胞中RhoA / ROCK通路，环氧合酶2表达和前列腺素E2的产生都有抑制作用。从饮食和补品中增加维生素D的摄入已显示出与BPH患病率降低相关。已显示每天高达6000 IU的维生素D类似物可减少BPH患者的前列腺体积。临床前试验表明，维生素D不仅能单独降低BPH细胞和前列腺细胞的增殖，而且在被已知的促进生长的分子（如IL-8，Des（1-3）IGF-1，睾丸激素和二氢睾丸激素）诱导时，维生素D也会降低。在所有研究中，维生素D摄入量增加没有任何副作用或负面影响。维生素D对前列腺量和BPH的影响已显示出令人鼓舞的结果，因此建议对维生素D和BPH进行进一步的研究。

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