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首页> 外文期刊>The international journal of developmental biology >Dlx3 is expressed in the ventral forebrain of chicken embryos: implications for the evolution of the Dlx gene family
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Dlx3 is expressed in the ventral forebrain of chicken embryos: implications for the evolution of the Dlx gene family

机译：Dlx3在鸡胚腹前脑中表达：对Dlx基因家族进化的影响

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The archetypal genomic arrangement of vertebrate Dlx genes is as three bigene clusters (Dlx1/2, Dlx3/4, Dlx5/6). Phylogenetic sequence analysis of mouse and zebrafish Dlx clusters supports the notion that the Dlx3/4 cluster is more derived and the absence of expression of either Dlx3 or Dlx4 in the central nervous system, as reported to date, is consistent with this. Together, these observations have prompted a model in which cis-regulatory elements, responsible for directing Dlx gene transcription in the forebrain, were lost from the Dlx3/4 bigene cluster prior to the divergence of tetrapods from fish. Here, we describe Dlx3 expression in the forebrain of chicken embryos; this constitutes the first documented evidence of expression of either Dlx3 or Dlx4 in the central nervous system of a vertebrate. Our observations have implications for models of the evolutionary history of the Dlx gene family, for the genomic organization of Dlx genes in birds and for functional redundancy of Dlx gene function during avian forebrain development.
机译：脊椎动物Dlx基因的原型基因组排列为三个双烯簇（Dlx1 / 2，Dlx3 / 4，Dlx5 / 6）。小鼠和斑马鱼Dlx簇的系统发生序列分析支持这样的观念，即Dlx3 / 4簇是更多衍生的，并且迄今为止报道的中枢神经系统中Dlx3或Dlx4的表达均与之相符。总之，这些发现促使人们建立了一个模型，在该模型中，负责引导前脑中Dlx基因转录的顺式调控元件在从鱼类中分离出四足动物之前就从Dlx3 / 4双烯簇中丢失了。在这里，我们描述了Dlx3在鸡胚前脑中的表达。这构成了脊椎动物中枢神经系统中Dlx3或Dlx4表达的第一个有据可查的证据。我们的观察结果对Dlx基因家族进化史的模型，鸟类中Dlx基因的基因组组织以及禽前脑发育过程中Dlx基因功能的功能冗余具有重要意义。

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