...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The international journal of lower extremity wounds >Autologous platelet gel: Five cases illustrating use on sickle cell disease ulcers
【24h】

Autologous platelet gel: Five cases illustrating use on sickle cell disease ulcers

机译：自体血小板凝胶：五例说明使用镰状细胞病溃疡

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Leg ulcers represent a particularly disabling complication in patients with sickle cell disease (SCD). Platelet gel (PG) is a novel therapeutic strategy used for accelerating wound healing of a wide range of tissues through the continuous release of platelet growth factors. Here, we describe the use of PG preparation according to Anitua's PRGF (preparations rich in growth factors) protocol for treating chronic nonhealing ulcers in patients with SCD. A positive response occurred in 3 patients with an area reduction of 85.7% to 100%, which occurred within 7 to 10 weeks, and a 35.2% and 20.5% of area reduction in 2 other patients, who however, had large ulcers. After calcium chloride addition, the platelet-rich plasmas demonstrated enhanced platelet-derived growth factors-BB (P <.001), transforming growth factor-β1 (P =.015), vascular endothelial growth factors (P =.03), and hepatocyte growth factors (nonsignificant) secretion. Furthermore, calcium chloride addition induced a significant decrease in platelet number (P =.0134) and there was no leukocyte detection in the PG product. These results demonstrate that PG treatment might impact the healing of leg ulcers in sickle cell disease, especially in patients with small ulcers.
机译：腿部溃疡是镰状细胞疾病（SCD）患者的特别致残并发症。血小板凝胶（PG）是一种新颖的治疗策略，可用于通过不断释放血小板生长因子来加速各种组织的伤口愈合。在这里，我们描述了根据Anitua的PRGF（富含生长因子的制剂）方案使用PG制剂治疗SCD患者的慢性不愈性溃疡的方法。 3例患者在7到10周内出现了阳性反应，面积减少了85.7％至100％，另外2例溃疡较大的患者则分别减少了35.2％和20.5％。加入氯化钙后，富含血小板的血浆表现出增强的血小板衍生生长因子-BB（P <.001），转化生长因子-β1（P = .015），血管内皮生长因子（P = .03）和肝细胞生长因子（无关紧要）的分泌。此外，添加氯化钙会导致血小板数量显着减少（P = .0134），并且在PG产品中未检测到白细胞。这些结果表明，PG治疗可能会影响镰状细胞病中腿部溃疡的愈合，特别是在小溃疡患者中。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号