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首页> 外文期刊>The international journal of developmental biology >Physiological and molecular characterisation of cadmium stress in Schmidtea mediterranea
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Physiological and molecular characterisation of cadmium stress in Schmidtea mediterranea

机译：Schmidtea mediterranea中镉胁迫的生理和分子特征

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摘要

The planarian Schmidtea mediterranea is a well-studied model organism for developmental research, because of its stem cell system. This characteristic also provides a unique opportunity to study stress management and the effect of stress on stem cells. In this study, we characterised the stress signature at different levels of biological organization. The carcinogenic metal cadmium was used as a model chemical stressor. We focused on stem cell activity and its interaction with other known stress parameters. Here, we have found that S. mediterranea is able to cope with high internal levels of cadmium. At endpoints such as size and mobility, cadmium-related stress effects were detected but all of these responses were transient. Correspondingly, cadmium exposure led to an elevated mitotic activity of the neoblasts, at the same time points when the other responses disappeared. At the molecular level, we observed redox-related responses that can be linked with both repair as well as proliferation mechanisms. Together, our results suggest that these animals have a high plasticity. The induction of stem cell activity may underlie this 'restoring' effect, although a carcinogenic outcome after longer exposure times cannot be excluded.
机译：涡虫Schmidtea mediterranea由于其干细胞系统而成为研究开发的模型生物。此特征还为研究压力管理以及压力对干细胞的影响提供了独特的机会。在这项研究中，我们表征了不同水平的生物组织的压力特征。致癌金属镉用作模型化学应激源。我们专注于干细胞活性及其与其他已知压力参数的相互作用。在这里，我们发现S. mediterranea能够应对内部高水平的镉。在大小和迁移率等端点，检测到镉相关的压力效应，但所有这些响应都是短暂的。相应地，在其他反应消失的同一时间点，镉暴露导致成胚细胞的有丝分裂活性升高。在分子水平上，我们观察到与氧化还原相关的反应，可以与修复以及增殖机制相关。总之，我们的结果表明这些动物具有很高的可塑性。干细胞活性的诱导可能是这种“恢复”作用的基础，尽管不能排除较长暴露时间后的致癌结果。

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