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首页> 外文期刊>The international journal of developmental biology >Regeneration of neuronal cell types in Schmidtea mediterranea: An immunohistochemical and expression study
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Regeneration of neuronal cell types in Schmidtea mediterranea: An immunohistochemical and expression study

机译：Schmidtea Mediterraterranea中神经元细胞类型的再生：免疫组织化学和表达研究

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Freshwater planarians are unique in their ability to regenerate a complete Central Nervous System (CNS) from almost any small piece of their body in just a few days. The planarian CNS contains a pair of anterior cephalic ganglia lying on top of two ventral nerve cords that extend along the length of the animal. Studies of planarian CNS regeneration have generally used pan-neural markers, which provide only a general overview of the process. Nevertheless, some reports have started to characterize the genes that are required for this process. In this study, to obtain a more detailed description of planarian neural regeneration, we monitored the regeneration of neuronal populations specifically labelled with antibodies against serotonin, allatostatin, neuropeptide F, GYRFamide and FMRFamide. We also characterized the regeneration of dopaminergic and octopaminergic cell populations by in situ hybridization. Finally, we characterized the expression pattern of a set of receptors for neurotransmitters, neuropeptides and hormones that are suggested to play a role in the regeneration process itself. Together, these data provide a more detailed description of the cellular events occurring during anterior and posterior CNS regeneration in planarians and provide the foundations for future mechanistic studies into the regeneration process in this important model system.
机译：淡水浮游动物的独特之处在于，他们能够在短短几天内从几乎任何身体小部位再生出完整的中枢神经系统（CNS）的能力。涡虫中枢神经系统包含一对前头神经节，它们位于沿着动物长度延伸的两条腹侧神经索的顶部。平面型CNS再生的研究通常使用泛神经标记，这些标记仅提供了该过程的一般概述。然而，一些报道已经开始表征该过程所需的基因。在这项研究中，为了获得对涡虫神经再生的更详细描述，我们监测了用抗5-羟色胺，阿托伐他汀，神经肽F，GYRFamide和FMRFamide抗体特异性标记的神经元群体的再生。我们还通过原位杂交表征了多巴胺能和章胺能细胞群的再生。最后，我们表征了一组神经递质，神经肽和激素的受体的表达模式，这些受体在再生过程本身中发挥作用。总之，这些数据提供了更详细的描述，在涡虫的前，后CNS再生过程中发生的细胞事件，并为该重要模型系统中再生过程的未来机理研究提供了基础。

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