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首页> 外文期刊>The international journal of developmental biology >Commitment of hematopoietic stem cells in avian and mammalian embryos: an ongoing story
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Commitment of hematopoietic stem cells in avian and mammalian embryos: an ongoing story

机译:禽和哺乳动物胚胎中造血干细胞的承诺:一个正在进行的故事

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摘要

During ontogeny, hematopoietic stem cells (HSC) become committed outside of hematopoietic organs. Once held to emerge from the yolk sac, they are currently thought to originate from the early aorta. However we now show that the allantois in the avian embryo and the placenta in the mouse embryo produce HSC in very large numbers. These sites thus appear to have a central role in the process of HSC emergence.
机译:在个体发育期间,造血干细胞(HSC)移到造血器官之外。一旦被认为从卵黄囊中出来,它们目前被认为起源于早期主动脉。但是,我们现在表明,禽类胚胎中的尿囊和小鼠胚胎中的胎盘会大量产生HSC。因此,这些位点似乎在HSC出现的过程中起着核心作用。

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