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首页> 外文期刊>The international journal of developmental biology >Regulatory T cells in the establishment and maintenance of self-tolerance: role of the thymic epithelium
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Regulatory T cells in the establishment and maintenance of self-tolerance: role of the thymic epithelium

机译：调节性T细胞在自我耐受中的建立和维持：胸腺上皮的作用

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The thymus constitutes the microenvironment for T lymphocyte differentiation and acquisition of self-tolerance. Aiming to specify the contributions of the two essential parts of the thymus, namely hemopoietic and epithelial, we have devised experimental models in birds and mice. Chimeric thymuses, xenogeneic in birds and allogeneic in mice, were constructed early in development. In both models we could demonstrate a critical role of the epithelial component of the thymic stroma in induction and maintenance of self-tolerance. These experiments showed that suppression mechanisms are also implicated in these events, strongly suggesting the existence of regulatory T cells in both models. Before these experiments the control of self-tolerance was usually attributed to suppressive cells. However, as the cell phenotypes were not identified, the role of these cells was disregarded. Numerous studies since our investigations argue in favour of regulatory mechanisms. The work we initiated several years ago represents a contribution to our understanding of the two linked and opposite aspects of immune-responded control, namely self-tolerance and autoimmunity.
机译：胸腺构成了T淋巴细胞分化和获得自我耐受的微环境。为了说明胸腺的两个基本组成部分，即造血和上皮的贡献，我们设计了鸟类和小鼠的实验模型。嵌合的胸腺在鸟类中是异种的，在小鼠中是同种的，在发育的早期就被构建了。在这两种模型中，我们都可以证明胸腺基质的上皮成分在诱导和维持自身耐受性中的关键作用。这些实验表明，抑制机制也与这些事件有关，强烈暗示了两种模型中都存在调节性T细胞。在这些实验之前，自我耐受的控制通常归因于抑制性细胞。但是，由于未鉴定细胞表型，因此忽略了这些细胞的作用。自从我们的调查以来，已有许多研究主张采用监管机制。几年前我们开展的工作代表了我们对免疫应答控制的两个相互联系和相反方面（即自我耐受和自身免疫）的理解的贡献。

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