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首页> 外文期刊>The international journal of developmental biology >Three developmental compartments involved in rib formation
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Three developmental compartments involved in rib formation

机译：涉及肋骨形成的三个发育区室

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摘要

When the thoracic somitic mesoderm was separated from the neural tube and the notochord with a piece of aluminum foil in two-day chick embryos, seven days after the operation ribs lacked their proximal part. The embryos were rescued by co-transplanting the notochord, the ventral half of neural tube, or QT6 cells transformed with Shh, on the somite side of the aluminum foil insert. Thus, proximal rib development depends on the notochord and the ventral neural tube, an effect which might be mediated through Shh secreted by these axial tissues. On the other hand, when the thoracic somitic mesoderm was separated from the surface ectoderm by a piece of polyethylene terephthalate film, the distal parts of the ribs were missing, suggesting that distal rib development depends on surface ectoderm. In these embryos, expression of Pax3 was weak and perturbed showing that the dermomyotome developed abnormally. It is not clear whether the development of distal rib is mediated by the dermomyotome, or the ectoderm. It has previously been shown that sternal rib development depends on lateral plate mesoderm. As to the distal rib, it is considered to be composed of two parts. Thus, the rib is composed of three developmental compartments, in agreement with a recently presented classification of somite derivatives as primaxial and abaxial.
机译：当在两天的雏鸡胚胎中用一块铝箔将胸廓中胚层与神经管和脊索分开时，手术后七天肋骨缺少了它们的近端部分。通过将脊索，神经管的腹侧半部或经Shh转化的QT6细胞共移植到铝箔插入物的侧面，可以挽救胚胎。因此，近端肋骨的发育取决于脊索和腹侧神经管，这种作用可能是由这些轴向组织分泌的Shh介导的。另一方面，当用一块聚对苯二甲酸乙二酯薄膜将胸廓中胚层与表面外胚层分开时，肋骨的远端部分消失了，这表明远端肋骨的发育取决于表面外胚层。在这些胚胎中，Pax3的表达较弱且受到干扰，表明皮肤子宫切除器发育异常。尚不清楚远端肋骨的发育是由真皮切开术还是外胚层介导的。先前已显示，胸骨肋骨发育取决于侧板中胚层。至于远端肋骨，它被认为是由两部分组成。因此，肋骨由三个发育区室组成，这与最近提出的somite衍生物的基本轴和背面轴分类一致。

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