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首页> 外文期刊>The International journal of drug policy >HCV synthesis project: preliminary analyses of HCV prevalence in relation to age and duration of injection.
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HCV synthesis project: preliminary analyses of HCV prevalence in relation to age and duration of injection.

机译：HCV合成项目：HCV流行率与注射年龄和注射时间的关系的初步分析。

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Early acquisition of hepatitis C virus (HCV) infection appears to affect a substantial proportion of injection drug users (IDUs)--between 20 percent and 90 percent. Analysing the range of HCV prevalence estimates in new injectors may help identify factors that can be modified to reduce HCV transmission. The HCV Synthesis Project is a meta-analysis of studies of HCV epidemiology and prevention in drug users worldwide. In this preliminary analysis, we examined data from 127 studies of IDUs that reported HCV prevalence in relation to age or year since onset of drug injection, analysing heterogeneity and calculating summary statistics where appropriate. Six studies reported gender-specific HCV prevalence rates among young or new injectors; the group mean prevalence was 47 percent for men and 44 percent for women (NS). Group mean age for HCV-negatives was 24.7 years (range 24-28) and 26.1 years (range 21-31) for HCV-positives (n=8 studies). Data were examined from 13 studies that compared HCV prevalence among young injectors to older injectors using 5-year age categories; substantial variation was present within these categories such that measures of central tendency were not calculated. Similarly, among studies reporting HCV prevalence among IDUs in relation to 1-year intervals of duration of injection (<1 year, <2 years, and <3 years), considerable variability was observed. Notably, there were studies in each category that reported prevalence of 70 percent or higher among recent-onset drug injectors. Our findings confirm previous studies reporting high risk of acquiring HCV shortly after onset of injection; thus, HCV prevention programmes must emphasize methods to reach new injectors. Future research should (1) report data on time to infection in depth, (2) provide detailed information on study methodology, and (3) characterize the research setting with respect to underlying factors that affect injection practices and networks. This will permit synthesis of a greater number of studies and may lead to the identification of factors that impede HCV transmission.
机译：早期感染丙型肝炎病毒（HCV）似乎影响了很大一部分注射吸毒者（IDU），介于20％至90％之间。分析新喷油器中HCV流行率估计值的范围可能有助于确定可以修改以减少HCV传播的因素。 HCV综合项目是一项针对全世界吸毒者的HCV流行病学和预防研究的荟萃分析。在此初步分析中，我们检查了127例IDU的研究数据，这些研究报告了自药物注射开始以来与年龄或年有关的HCV患病率，分析了异质性并在适当的情况下计算了汇总统计数据。六项研究报告了年轻或新注射者中特定于性别的HCV流行率;该组的平均患病率是男性为47％，女性为44％（NS）。 HCV阴性组的平均年龄为24.7岁（范围24-28），HCV阳性组的平均年龄为26.1岁（范围21-31）（n = 8研究）。从13个研究中检查了数据，这些研究使用5岁年龄组比较了年轻喷射器和较老喷射器的HCV流行率;这些类别中存在很大的差异，因此没有计算集中趋势的度量。同样，在报告注射毒品使用者中与注射间隔1年间隔（<1年，<2年和<3年）相关的HCV患病率的研究中，观察到了很大的变异性。值得注意的是，在每个类别中都有研究报告，最近发作的药物注射者中的患病率达到70％或更高。我们的研究结果证实了先前的研究报告，即在注射后不久就有高风险感染HCV。因此，HCV预防计划必须强调达到新喷油嘴的方法。未来的研究应（1）深入报告感染时间的数据，（2）提供有关研究方法的详细信息，以及（3）就影响注射实践和网络的潜在因素来表征研究背景。这将允许进行更多研究的综合，并可能导致发现阻碍HCV传播的因素。

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