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首页> 外文期刊>The international journal of developmental biology >Cellular dynamics and molecular control of the development of organizer-derived cells in quail-chick chimeras
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Cellular dynamics and molecular control of the development of organizer-derived cells in quail-chick chimeras

机译：鹌鹑嵌合体的组织动力学来源的细胞动力学和分子控制。

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Malformations affecting the nervous system in humans are numerous and various in etiology. Many are due to genetic deficiencies or mechanical accidents occurring at early stages of development. It is thus of interest to reproduce such human malformations in animal models. The avian embryo is particularly suitable for researching the role of morphogenetic movements and genetic signaling during early neurogenesis. The last ten years of research with Nicole Le Douarin in the Nogent Institut have brought answers to questions formulated by Etienne Wolff at the beginning of his career, by showing that Hensen's node,the avian organizer, is at the source of all the midline cells of the embryo and ensures cell survival, growth and differentiation of neural and mesodermal tissues.
机译：影响人类神经系统的畸形在病因学上是多种多样的。许多是由于在发育早期发生的遗传缺陷或机械事故。因此，有兴趣在动物模型中重现这种人类畸形。禽胚胎特别适合于研究早期神经发生过程中形态发生运动和遗传信号的作用。在Nogent Institut中与Nicole Le Douarin进行的最近十年研究为埃蒂安·沃尔夫（Etienne Wolff）在其职业生涯初期提出的问题提供了答案，这表明禽类组织者Hensen的结节是所有中线细胞的来源胚胎，并确保神经和中胚层组织的细胞存活，生长和分化。

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