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首页> 外文期刊>The international journal of developmental biology >The human T cell immune response to Epstein-Barr virus
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The human T cell immune response to Epstein-Barr virus

机译：人类T细胞对爱泼斯坦-巴尔病毒的免疫反应

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The Epstein-Barr virus (EBV) is a gamma-herpes virus which establishes latent, lifelong infection in more than 95% of the human adult population. Despite its growth transforming capacity, most carriers control EBV associated malignacies efficiently and remain free of EBV+ tumors. Though EBV is controlled by a potent immune response, this virus uses latency to persist in vivo. This review summarizes work which has been done to characterize T cell responses to EBV. The CD8 T cell responses are rather well characterized and have been shown by several groups to be highly focused towards early lytic antigens. Much less is known about CD4 T cell epitopes, due to the small size of the CD4 compartment. However, recent data indicate a control of lytic and latent cycles of EBV by specific CD4+ T cells. A clear understanding of the T cell response to EBV is important with a view to developing immunotherapies for the virus and its related malignancies.
机译：爱泼斯坦巴尔病毒（EBV）是一种伽马疱疹病毒，可在95％以上的成年人口中建立潜在的终身感染。尽管具有增长转化能力，但大多数携带者仍能有效控制EBV相关的恶性肿瘤，并且保持无EBV +肿瘤。尽管EBV受有效的免疫反应控制，但该病毒利用潜伏期在体内持续存在。这篇综述总结了表征T细胞对EBV反应的工作。 CD8 T细胞反应已被很好地表征，并已被多个研究组高度关注早期裂解抗原。由于CD4区室较小，对CD4 T细胞表位的了解很少。但是，最近的数据表明，特定CD4 + T细胞可控制EBV的裂解和潜伏周期。为了开发针对病毒及其相关恶性肿瘤的免疫疗法，清楚了解T细胞对EBV的反应非常重要。

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