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首页> 外文期刊>The International journal of drug policy >Self-reported side-effects of anti-retroviral treatment among IDUs: a 7-year longitudinal study (APROCO-COPILOTE COHORT ANRS CO-8).
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Self-reported side-effects of anti-retroviral treatment among IDUs: a 7-year longitudinal study (APROCO-COPILOTE COHORT ANRS CO-8).

机译：IDU中抗逆转录病毒治疗的自我报告的副作用：一项为期7年的纵向研究（APROCO-COPILOTE COHORT ANRS CO-8）。

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The introduction of potent anti-retroviral treatment (ART) has transformed HIV disease into a chronic condition with the prospect, for the patient, of strict adherence to effective but life-long treatments. Within this framework, a major issue that can negatively affect adherence is the side-effects of the treatment. To date, studies documenting how individuals HIV-infected through drug injection (IDUs) experience ART-related side effects are sparse. Longitudinal data collected from the APROCO-COPILOTE cohort have been used to compare the experience of ART-related side-effects who have been HIV-infected via injecting drug use and non-IDU patients. A 20-item list was used to collect self-reported side-effects over a 7-year follow up period. Of 922 patients, 15% were IDUs. At any given visit, IDUs reported a significantly higher number of side-effects and had approximately twice the risk of reporting any side effect than non-IDUs. Most commonly reported side-effects were dry skin, fatigue, vomiting, bonetroubles, insomnia. After adjustment for social conditions, depressive symptoms, use of sleeping pills and time since HIV diagnosis, IDUs reported experiencing significantly more side-effects than non-IDUs. Whether or not this is related to sensitivity to pain or to other comorbidities is difficult to establish. Further research is needed to understand how substitution treatment can mediate the relationship between exposure to opioids and side-effects. Providing appropriate care to reduce side-effects, thereby increasing adherence to ART in this population, remains a major challenge especially in those countries scaling up ART. Incorporating symptom management and improving access to analgesic medications within a model of comprehensive care for HIV-infected IDUs, could reduce the impact of drug-related and HIV-related harms and induce better long-term treatment outcomes and quality of life.
机译：有效的抗逆转录病毒治疗（ART）的引入已将HIV疾病转变为慢性疾病，对患者而言，有望严格遵守有效但终生的治疗方法。在此框架内，可能对依从性产生负面影响的主要问题是治疗的副作用。迄今为止，有关通过药物注射（IDU）感染HIV的个体如何经历ART相关副作用的研究很少。从APROCO-COPILOTE队列收集的纵向数据已用于比较通过注射吸毒和非IDU患者感染HIV的ART相关副作用的经验。在长达7年的随访期内，使用了20项清单来收集自我报告的副作用。在922名患者中，有15％是注射毒品使用者。在任何给定的访问中，IDU报告的副作用数量均显着高于非IDU，报告任何副作用的风险大约是非IDU的两倍。最常报告的副作用是皮肤干燥，疲劳，呕吐，骨骼不适，失眠。在调整了社会条件，抑郁症状，使用安眠药和自诊断出艾滋病毒以来的时间之后，注射毒品者的副作用要比非注射毒品者要多得多。很难确定这是否与疼痛敏感性或其他合并症有关。需要进一步的研究来了解替代治疗如何介导阿片类药物的暴露与副作用之间的关系。提供适当的护理以减少副作用，从而增加该人群的抗逆转录病毒依从性，仍然是一项重大挑战，尤其是在那些扩大抗逆转录病毒疗法的国家。在针对艾滋病毒感染的注射毒品使用者的全面护理模型中，将症状管理与改善止痛药的使用相结合，可以减少药物相关和艾滋病毒相关危害的影响，并带来更好的长期治疗效果和生活质量。

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