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首页> 外文期刊>The international journal of artificial organs >Elimination of meropenem by continuous hemo(dia) filtration: an in vitro one-compartment model.
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Elimination of meropenem by continuous hemo(dia) filtration: an in vitro one-compartment model.

机译：通过持续的血液过滤（直径）消除美罗培南：一种体外单室模型。

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Meropenem is a carbapenem antibiotic with a wide spectrum of activity against most gram positive and gram negative bacteria including anaerobes. Dose adjustments are necessary during continuous renal replacement therapies of acute renal failure. This in vitro study was conducted to investigate the influence of different filter materials, surface areas (AN-69 0.6 m2 and 0.9 m2, polysulfone 0.75 m2, polyamide 0.6 m2), and increasing flow rates (from 3.3 - 26.7 ml/min) on the elimination of meropenem in an in vitro continuous hemo(dia)filtration model. Meropenem was measured using HPLC with UV-detection. While the clearance increased proportionally to increasing dialysate flow rates in filters with a surface area of 0.9 m2, a peak clearance was reached in the small filters at flow rates of 10.0 ml/min (polyamide 0.6 m2) and 18.3 ml/min (AN-69 0.6 m2), when tested under the same conditions. This indicated incomplete dialysate saturation due to the diminished time available for meropenem to equilibrate with the dialysate solution. No adsorption to either of the tested membranes was detected. Dosage recommendations derived from clinical studies might be appropriate when different filter materials, but similar operational settings of the continuous replacement therapy, are applied. Reduction of the recommended dose might be necessary, when renal replacement therapies with lower flow rates and/or filters with smaller surface areas are carried out.
机译：美罗培南是碳青霉烯类抗生素，对大多数革兰氏阳性和革兰氏阴性细菌（包括厌氧菌）具有广泛的活性。在连续性肾脏替代疗法治疗急性肾功能衰竭期间，需要调整剂量。进行了这项体外研究，以调查不同过滤材料，表面积（AN-69 0.6平方米和0.9平方米，聚砜0.75平方米，聚酰胺0.6平方米）以及流速（从3.3-26.7毫升/分钟）增加对过滤器的影响。体外连续血液透析过滤模型中美罗培南的消除。美罗培南是使用HPLC和UV检测进行测量的。虽然清除率与表面积为0.9 m2的过滤器中的透析液流速成比例地增加，但在小型过滤器中，流速分别为10.0 ml / min（聚酰胺0.6 m2）和18.3 ml / min（AN- 69 0.6 m2），在相同条件下进行测试。这表明由于美罗培南与透析液溶液平衡所需的时间缩短，透析液饱和度不完全。没有检测到对任何一种测试膜的吸附。当使用不同的过滤材料但采用连续更换疗法的类似操作设置时，从临床研究得出的剂量建议可能是适当的。当进行流速较低的肾脏替代治疗和/或表面积较小的过滤器时，可能需要减少推荐剂量。

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