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首页> 外文期刊>Biological psychiatry >Gene x environment interactions in complex behavior: First, build a telescope.
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Gene x environment interactions in complex behavior: First, build a telescope.

机译：基因x环境在复杂行为中的相互作用：首先，建立望远镜。

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Several common alleles that should, because of their functionality, alter stress response have been discovered to do exactly that. They lead to long-lasting differences in depression, anxiety, suicidality, and impulsivity. The short list of genes harboring such alleles includes FKBP5, which has been specifically related to posttraumatic stress disorder (PTSD) (1), the serotonin transporter, brain-derived neurotrophic factor, cate-chol-O-methyltransferase (COMT), monoamine oxidase A, and neuropeptide Y (NPY). In several instances, the allele effect was entirely within stress-exposed individuals; furthermore, an endocrine (testosterone) context dependency was found for monoamine oxidase A (2). For the five of these six genes for which effects of stress-related functional loci have been measured on so-called intermediate phenotypes, in each instance the effect was far more profound (3-7), encouraging the development of a new discipline, "imaging genetics." Within one study, effects of a functional NPY promoter variant were progressively diluted from the molecular level (brain NPY messenger RNA and plasma peptide concentrations), to brain imaging responses to pain and emotional probes and finally to the more complex level of anxiety (7).
机译：已经发现由于其功能而应改变压力反应的几种常见等位基因正好可以做到这一点。它们导致抑郁，焦虑，自杀和冲动方面的持久差异。包含此类等位基因的基因的简短列表包括FKBP5，它与创伤后应激障碍（PTSD）（1），血清素转运蛋白，脑源性神经营养因子，儿茶酚-O-甲基转移酶（COMT），单胺氧化酶特别相关。 A和神经肽Y（NPY）。在某些情况下，等位基因效应完全在压力暴露的个体内发生。此外，发现单胺氧化酶A对内分泌（睾丸激素）的依赖性（2）。对于已经测量了与压力相关的功能基因座对所谓的中间表型的影响的这六个基因中的五个，在每种情况下，影响都更为深远（3-7），这鼓励了新学科的发展，“成像遗传学。”在一项研究中，功能性NPY启动子变体的作用逐渐从分子水平（脑NPY信使RNA和血浆肽浓度）被稀释到对疼痛和情绪探针的脑成像反应，最后到更复杂的焦虑水平（7）。 。

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